prikaz prve stranice dokumenta Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients
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Scientific paper - Original scientific paper
Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients
International urology and nephrology, 48 (2016), 7; 1145-1154. https://doi.org/10.1007/s11255-016-1275-2
Kocijančić, Marija; Čubranić, Zlatko; Vujičić, Božidar; Rački, Sanjin; Dvornik, Štefica; Zaputović, Luka

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Kocijančić, M., Čubranić, Z., Vujičić, B., Rački, S., Dvornik, Š. & Zaputović, L. (2016). Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients. International urology and nephrology, 48. (7), 1145-1154. doi: 10.1007/s11255-016-1275-2

Kocijančić, Marija, et al. "Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients." International urology and nephrology, vol. 48, no. 7, 2016, pp. 1145-1154. https://doi.org/10.1007/s11255-016-1275-2

Kocijančić, Marija, Zlatko Čubranić, Božidar Vujičić, Sanjin Rački, Štefica Dvornik and Luka Zaputović. "Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients." International urology and nephrology 48, no. 7 (2016): 1145-1154. https://doi.org/10.1007/s11255-016-1275-2

Kocijančić, M., et al. (2016) 'Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients', International urology and nephrology, 48(7), pp. 1145-1154. doi: 10.1007/s11255-016-1275-2

Kocijančić M, Čubranić Z, Vujičić B, Rački S, Dvornik Š, Zaputović L. Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients. International urology and nephrology [Internet]. 2016 [cited 2024 December 22];48(7):1145-1154. doi: 10.1007/s11255-016-1275-2

M. Kocijančić, Z. Čubranić, B. Vujičić, S. Rački, Š. Dvornik and L. Zaputović, "Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients", International urology and nephrology, vol. 48, no. 7, pp. 1145-1154, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:623550. [Accessed: 22 December 2024]

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Title (english)Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients
AuthorMarija Kocijančić
AuthorZlatko Čubranić
AuthorBožidar Vujičić
AuthorSanjin Rački
AuthorŠtefica Dvornik
AuthorLuka Zaputović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Purpose. Atherosclerotic cardiovascular complications represent significant cause of mortality in hemodialysis (HD) patients. The aims of this study were to: (a) investigate association of sICAM-1, sVCAM-1, omentin-1 and other non-traditional risk factors with subclinical atherosclerosis ; (b) examine the diagnostic value of these specific markers in the early detection of subclinical atherosclerosis ; and (c) examine their role as predictors of mortality in group of patients with subclinical atherosclerosis on regular HD. Materials and methods. Starting from November 2011, a cohort of 210 HD patients participated in this 3-year follow-up study. The subjects were divided into three groups according to the presence of atherosclerosis. Atherosclerotic disease was assessed by measuring carotid intima-media thickness (IMT). Samplings were withdrawn at baseline and thereafter every 12 months until the end of follow-up. Results. IMT showed weak correlation with sICAM-1 (r = 0.39, P = 0.001), sVCAM-1 (r = 0.27, P = 0.015) and omentin-1 (r = −0.25, P = 0.020), and also omentin-1 showed good correlation with parameters of systolic and diastolic function (r = 0.52, P = 0.001 and r = 0.51, P = 0.001). Multivariate analysis showed that sICAM-1 and sVCAM-1 concentrations were a strong independent correlate of IMT (P = 0.031 and P = 0.010, respectively). The Cox proportional analysis showed that sICAM-1 and omentin-1 concentrations were strong predictors of cardiovascular death (HR 1.85, CI 1.18–2.32, P = 0.021 and HR 4.14, CI 1.38–12.1, P = 0.004, respectively) and that serial measurements of these markers predict IMT progression (HR 1.98, 95% CI 1.21–2.38, P < 0.002 and HR 2.91, 95% CI 1.57–4.72, P < 0.001, respectively). Conclusions. Our study demonstrated that sICAM-1 and omentin-1 levels are strong predictors of cardiovascular death in HD patients with subclinical atherosclerosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational urology and nephrology
Numberingvol. 48, no. 7, pp. 1145-1154
p-ISSN0301-1623
DOIhttps://doi.org/10.1007/s11255-016-1275-2
URN:NBNurn:nbn:hr:184:623550
Publication2016
Document URLhttp://bib.irb.hr/855918
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-09 12:45:54