prikaz prve stranice dokumenta Melanoma can control development of metastasis – Fact or myth?
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Scientific paper - Original scientific paper
Melanoma can control development of metastasis – Fact or myth?
Medical Hypotheses, 89 (2016); 65-67. https://doi.org/10.1016/j.mehy.2016.02.009
Čabrijan, Leo; Batinac, Tanja; Lipozenčić, Jasna

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Čabrijan, L., Batinac, T. & Lipozenčić, J. (2016). Melanoma can control development of metastasis – Fact or myth?. Medical Hypotheses, 89., 65-67. doi: 10.1016/j.mehy.2016.02.009

Čabrijan, Leo, et al. "Melanoma can control development of metastasis – Fact or myth?." Medical Hypotheses, vol. 89, 2016, pp. 65-67. https://doi.org/10.1016/j.mehy.2016.02.009

Čabrijan, Leo, Tanja Batinac and Jasna Lipozenčić. "Melanoma can control development of metastasis – Fact or myth?." Medical Hypotheses 89 (2016): 65-67. https://doi.org/10.1016/j.mehy.2016.02.009

Čabrijan, L., Batinac, T. and Lipozenčić, J. (2016) 'Melanoma can control development of metastasis – Fact or myth?', Medical Hypotheses, 89, pp. 65-67. doi: 10.1016/j.mehy.2016.02.009

Čabrijan L, Batinac T, Lipozenčić J. Melanoma can control development of metastasis – Fact or myth?. Medical Hypotheses [Internet]. 2016 April [cited 2024 November 02];89:65-67. doi: 10.1016/j.mehy.2016.02.009

L. Čabrijan, T. Batinac and J. Lipozenčić, "Melanoma can control development of metastasis – Fact or myth?", Medical Hypotheses, vol. 89, pp. 65-67, April 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:707956. [Accessed: 02 November 2024]

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Metadata
Title (english)Melanoma can control development of metastasis – Fact or myth?
AuthorLeo Čabrijan
AuthorTanja Batinac
AuthorJasna Lipozenčić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Abstract The malignant melanoma spreading process cannot explain occurrence of metastases several years following local surgical therapy of primary malignancy. But, this complex process of delayed metastases is still challenging and not completely understood. We hypotheses that melanoma metastases occur early in disease, probably at the same time with the occurrence of the primary melanoma. We suggest that dissemination of metastatic "seed cells" occur at an early stage of the disease together with the development of primary melanoma and cannot be detected by standard diagnostic methods. These cells are masked between healthy cells and have the potential to proceed in true metastasis following the activation triggered by signal from primary tumor or other source. Other possibility includes the existence of two different genes, one responsible for development of primary melanoma, and the other with a roll in development of metastases. We believe that future investigation should be directed toward better understanding of mechanisms involved in metastases development keeping in mind that melanoma behavior is irrational and defies logical thinking.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Hypotheses
Numberingvol. 89, pp. 65-67
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2016.02.009
URN:NBNurn:nbn:hr:184:707956
Publication2016-04
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0306987716000517
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-18 14:07:54