prikaz prve stranice dokumenta Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia
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Scientific paper - Original scientific paper
Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia
Collegium antropologicum, 36 supplement 2 (2012), 2; 87-91. urn:nbn:hr:184:713367
Braut, Tamara; Kujundžić, Milodar; Vukelić, Jelena; Manestar, Dubravko; Krstulja, Mira; Starčević, Radan; Grahovac, Blaženka

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Braut, T., Kujundžić, M., Vukelić, J., Manestar, D., Krstulja, M., Starčević, R. & Grahovac, B. (2012). Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia. Collegium antropologicum, 36 supplement 2. (2), 87-91. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:713367

Braut, Tamara, et al. "Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia." Collegium antropologicum, vol. 36 supplement 2, no. 2, 2012, pp. 87-91. https://urn.nsk.hr/urn:nbn:hr:184:713367

Braut, Tamara, Milodar Kujundžić, Jelena Vukelić, Dubravko Manestar, Mira Krstulja, Radan Starčević and Blaženka Grahovac. "Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia." Collegium antropologicum 36 supplement 2, no. 2 (2012): 87-91. https://urn.nsk.hr/urn:nbn:hr:184:713367

Braut, T., et al. (2012) 'Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia', Collegium antropologicum, 36 supplement 2(2), pp. 87-91. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713367 (Accessed 20 November 2024)

Braut T, Kujundžić M, Vukelić J, Manestar D, Krstulja M, Starčević R, and sur.. Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia. Collegium antropologicum [Internet]. 2012 [cited 2024 November 20];36 supplement 2(2):87-91. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713367

T. Braut, et al., "Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia", Collegium antropologicum, vol. 36 supplement 2, no. 2, pp. 87-91, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713367. [Accessed: 20 November 2024]

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Metadata
Title (english)Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia
AuthorTamara Braut
AuthorMilodar Kujundžić
AuthorJelena Vukelić
AuthorDubravko Manestar
AuthorMira Krstulja
AuthorRadan Starčević
AuthorBlaženka Grahovac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract (english)
The study searched for epidermal growth factor receptor (EGFR) gene amplification in hyperplastic glottis lesions. After classical pathohistological findings of hematoxylin-eosin (HE) slides and quantitative immunohistochemical (IHC) analysis, fluorescent in situ hybridization (FISH) was used on tissue microarrays of laryngeal hyperplastic tissue ranging from normal mucosa to abnormal and atypical hyperplastic lesions. FISH analysis of two atypical hyperplastic lesions discovered the amplification of EGFR gene while it was not found in simple and abnormal hyperplastic lesions. The results may indicate that EGFR gene amplifications could possibly correlate with the histopathologic picture. Tissue samples burdened with specific oncogen signatures like EGFR gene amplification could be detected in precancerous lesion. This might improve follow-up and treatment protocols of glottic lesions which are an everyday problem for ENT practitioners. Further research is mandatory to confirm our findings.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 36 supplement 2, no. 2, pp. 87-91
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:713367
Publication2012
Document URLhttps://hrcak.srce.hr/96462
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2022-02-02 08:42:41