Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands

Handke, W.; Luig, C.; Popović, Branka; Krmpotić, Astrid; Jonjić, Stipan; Brune, Wolfram

doi:10.1128/JVI.02657-12

prikaz prve stranice dokumenta Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands

Download
PDF 1.3 MB

Scientific paper - Original scientific paper

Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands

Journal of Virology, 87 (2013), 6; 3592-3596. https://doi.org/10.1128/JVI.02657-12

Handke, W.; Luig, C.; Popović, Branka; Krmpotić, Astrid; Jonjić, Stipan; Brune, Wolfram

Cite this document

APA 6th Edition

Handke, W., Luig, C., Popović, B., Krmpotić, A., Jonjić, S. & Brune, W. (2013). Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands. Journal of Virology, 87. (6), 3592-3596. doi: 10.1128/JVI.02657-12

MLA 8th Edition

Handke, W., et al. "Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands." Journal of Virology, vol. 87, no. 6, 2013, pp. 3592-3596. https://doi.org/10.1128/JVI.02657-12

Chicago 17th Edition

Handke, W., C. Luig, Branka Popović, Astrid Krmpotić, Stipan Jonjić and Wolfram Brune. "Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands." Journal of Virology 87, no. 6 (2013): 3592-3596. https://doi.org/10.1128/JVI.02657-12

Harvard

Handke, W., et al. (2013) 'Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands', Journal of Virology, 87(6), pp. 3592-3596. doi: 10.1128/JVI.02657-12

Vancouver

Handke W, Luig C, Popović B, Krmpotić A, Jonjić S, Brune W. Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands. Journal of Virology [Internet]. 2013 January 09 [cited 2024 December 25];87(6):3592-3596. doi: 10.1128/JVI.02657-12

IEEE

W. Handke, C. Luig, B. Popović, A. Krmpotić, S. Jonjić and W. Brune, "Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands", Journal of Virology, vol. 87, no. 6, pp. 3592-3596, January 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:801946. [Accessed: 25 December 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:801946

Please login to the repository to save this object to your list.

Metadata

Title (english)	Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands
Author	W. Handke
Author	C. Luig
Author	Branka Popović
Author	Astrid Krmpotić
Author	Stipan Jonjić
Author	Wolfram Brune
Author's institution	University of Rijeka Faculty of Medicine (Department of Histology and Embryology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (english)	Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1(-/-) mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Journal of Virology
Numbering	vol. 87, no. 6, pp. 3592-3596
p-ISSN	0022-538X
DOI	https://doi.org/10.1128/JVI.02657-12
URN:NBN	urn:nbn:hr:184:801946
Publication	2013-01-09
Publication	2013-03-15
Document URL	http://jvi.asm.org/cgi/doi/10.1128/JVI.02657-12
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2018-11-08 10:43:25