master's thesis
USPOREDBA VENSKOG I PROTETSKOG PRESATKA PRI FEMOROPOPLITEALNOM PREMOŠTENJU (PAD)

Tea Ratković (2015)
Sveučilište u Rijeci
Medicinski fakultet
Katedra za kirurgiju
Metadata
TitleUSPOREDBA VENSKOG I PROTETSKOG PRESATKA PRI FEMOROPOPLITEALNOM PREMOŠTENJU (PAD)
AuthorTea Ratković
Mentor(s)Miljenko Kovačević (thesis advisor)
Abstract
Periferna arterijska bolest (PAD) je uzrokovana sistemskom aterosklerozom, a manifestira se različitim simptomima i znakovima koji ukazuju na ishemiju ekstremiteta. Prevalencija bolesti raste progresivno s dobi. Glavni čimbenici rizika nastanka periferne arterijske bolesti su dob, spol, rasa, pušenje, šećerna bolest, arterijska hipertenzija, hiperlipidemija, hiperhomocisteinemija. Simptomi periferne arterijske bolesti donjih ekstremiteta su intermitentne klaudikacije, bolovi u mirovanju te ishemijske ulceracije i gangrene. Periferna arterijska bolest često dovodi do nastanka lezija u femoropoplitealnom segmentu. U klasifikaciji lezija femoropoplitealnog područja koriste se TASC smjernice. TASC smjernice su utemeljene na morfološkim karakteristikama lezija te sadrže preporuke za početno liječenje. Liječenje pacijenata ovisi o težini simptoma, a kod asimptomatskih bolesnika potrebna je redovita kontrola i korekcija rizičnih čimbenika. Od farmakoloških lijekova najčešće se koriste antihipertenzivi, antiagregacijski lijekovi, statini, vazodilatatori, prostaglandini, inhibitori fosfodiesteraze te antagonisti 5-HT2 receptora. Endovaskularna metoda se koristi u liječenju stenoza ili kratkih okluzija femoropoplitealnog područja te ona predstavlja alternativnu metodu revaskularizacije kod pacijenata koji zbog komorbiditeta ne mogu biti podvrgnuti angiokirurškoj metodi premoštenja. Angiokirurška metoda premoštenja pomoću presatka i dalje predstavlja zlatni standard u liječenju dugih lezija femoropoplitealnog područja. Pri femoropoplitealnom premoštenju koriste se venski i protetski (PTFE, Dacron) presadci. Protetski presadci predstavljaju alternativnu metodu, no autologna vena safena i dalje predstavlja prvi izbor pri premoštenju.
Keywordsperipheral artery disease atherosclerosis TASC guidelines femoro-popliteal lesions endovascular methods bypass saphenous vein prosthetic grafts.
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za kirurgiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2015
Parallel abstract (English)
Peripheral arterial disease (PAD) is caused by systemic atherosclerosis, manifested by various symptoms and signs suggestive of extremity ischemia. The prevalence of the disease increases progressively with age. The main risk factors of peripheral arterial disease are age, sex, race, smoking, diabetes, hypertension, hyperlipidemia, hyperhomocysteinemia. Symptoms of peripheral arterial disease of the lower extremities are intermittent claudication, pain at rest and ischemic ulceration and gangrene. Peripheral arterial disease often leads to the formation of lesions in femoro- popliteal area. For classification of lesions in femoropopliteal area are used TASC guidelines. TASC guidelines are based on morphological characteristics of the lesion and contain recommendations for initial treatment. Treatment of patients depending on the severity of symptoms, and asymptomatic patients require regular control and correction of risk factors. Pharmacological drugs commonly used are antihypertensive agents, antiplatelet agents, statins, vasodilators, prostaglandins, phosphodiesterase inhibitors and antagonists of 5-HT2 receptors. Endovascular methods is used in treating stenosis or occlusion of short femoropopliteal area and it is an alternative method of revascularization in patients that because of comorbidity can't be expose to bypass method. Method using the bypass graft is still the gold standard in the treatment of long lesions in femoro-popliteal area. In femoro-popliteal bypass we can use a venous and prosthetic (PTFE, Dacron) grafts. Prosthetic grafts represent an alternative method, but autologous saphenous vein is still the first choice for bypass.
Parallel keywords (Croatian)periferna arterijska bolest ateroskleroza TASC smjernice femoropoplitealne lezije endovaskularna metoda angiokirurška metoda premoštenja vena safena protetski presadci.
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:327364
CommitterBosa Licul