Access restricted to higher education institution's students and staff
master's thesis
POREMEĆAJ NEUROENDOKRINE MODULACIJE U SHIZOFRENIJI

Jasmina Omeragić (2015)
Metadata
TitlePOREMEĆAJ NEUROENDOKRINE MODULACIJE U SHIZOFRENIJI
AuthorJasmina Omeragić
Mentor(s)Gordana Rubeša (thesis advisor)
Abstract
Uzrok shizofrenije ostaje i dalje nepoznat. Danas se smatra da bi shizofrenija mogla biti heterogena s obzirom na etiologiju i da različiti mehanizmi uzrokuju više podtipova bolesti. Endokrini poremećaji često su udruženi sa sekundarnim psihijatrijskim simptomima, dok s druge strane, značajan postotak pacijenata sa definiranim psihijatrijskim sindromima pokazuje obrasce endokrine disfunkcije. Pregled literature pokazuje postojanje abnormalnosti u razini tireoidnih hormona, estrogena, testosterona, kortizola, prolaktina i oksitocina kod shizofrenih bolesnika, ali i adolescenata sa povećanim rizikom za razvoj shizofrenije. Pregledom novih istraživanja ističe se značaj nekoliko ranijih hipoteza, uključujući hipotezu hipoestrogenizma i hipotezu o protektivnom učinku estrogena. Postoji sve veći interes za primjenu SERM-a kao adjuvantne terapije u shizofreniji, ali i za intranazalnu primjenu oksitocina. Hipoteza da HPA aktivnost i neuroendokrine abnormalnosti mogu potaknuti ekspresiju psihotičnih simptoma potvrđuje se novim istraživanjima, sa znantno većim brojem ispitanika. Hiperprolaktinemija se javlja kao nuspojava liječenja, ali se nedavno otkriva i u skupini pacijenata sa prvom epizodom psihoze, koji su bez terapije. Primjenom oksitocina u amigdalu postiže se poboljšanje kod socijalnog povlačenja, a pokušava se objasniti hipotezom da je utjecaj oksitocina na socijalno ponašanje posredovan interakcijom dijelova amigdale za obradu emocija i njezinih dopaminskih veza.
Keywordsschizophrenia psychoneuroendocrinology hormones thyroid estrogen testosterone prolactin oxytocin cortisol
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za psihijatriju i psihološku medicinu
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2015
Parallel abstract (English)
The cause of schizophrenia remains unknown. Today, it is considered that schizophrenia might be heterogenous considering its etiology and that different mechanism cause more disease subtypes. Endocrine disorders are often combined with secondary psychiatric symptoms, while on the other hand, a significant percentage of patients with defined psychiatric syndromes show patterns of endocrine dysfunction. The literature review shows the existence of abnormal thyroid hormone, estrogen, testosterone, cortisol, prolactin and oxytocin levels in schizophrenic patients, but also in adolescents at high risk for schizophrenia. By reviewing new studies, several previous hypotheses are highlighted, including hypoestrogenism hypothesis and estrogen protection hypothesis There is increasing interest in the application of SERMs as adjunctive therapy in schizophrenia, and intranasal administration of oxytocin The hypothesis that the HPA activity and neuroendocrine abnormalities can trigger the expression of psychotic symptoms is confirmed by new research, with a substantially larger number of participants. Hyperprolactinemia occurs as a side effect of treatment, but it is recently revealed in a group of patients with first episode of psychosis, who were without therapy By applying oxytocin in the amygdala, improvement in social withdrawal is achieved and this might be explained by the hypothesis that the effect of oxytocin in social behavior is mediated by the interaction of emotion-processing parts of amygdala and its dopaminergic connections.
Parallel keywords (Croatian)shizofrenija psihoneuroendokrinologija hormoni tiroidni estrogen testosteron prolaktin oksitocin kortizol
Resource typetext
Access conditionAccess restricted to higher education institution's students and staff
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:006284
CommitterBosa Licul