Professional paper - Review paper
Involvement of ion channels in temporomandibular disorders

Simonić-Kocijan, Sunčana; Tariba, Petra; Badel, Tomislav; Kovačević Pavičić, Daniela; Uhač, Ivone (2013)
Metadata
Language Croatian
Title (Croatian)Povezanost temporomandibularnih poremećaja s promjenama u ekspresiji ionskih kanala
Title (English)Involvement of ion channels in temporomandibular disorders
AuthorSimonić-Kocijan, Sunčana
Tariba, Petra
Badel, Tomislav
Kovačević Pavičić, Daniela
Uhač, Ivone
Abstract (Croatian)
Temporomandibularni poremećaji (TMP) obuhvaćaju niz kliničkih stanja karakteriziranih promjenama žvačne muskulature, temporomandibularnih zglobova (TMZ) i pridruženih struktura. Prema istraživanjima u SAD-u i Europi kronični orofacijalni bol obuhvaća 40 % svih kroničnih bolnih stanja, a od toga je 10 – 15 % vezano uz TMP. Bol i preosjetljivost žvačnih mišića i TMZ-a navode se kao vodeći simptomi TMP-a. Iako etiopatogeneza TMP-a nije u potpunosti razjašnjena, u osoba s TMP-om uočene su promjene u procesuiranju bolnih podražaja, što ukazuje na važnost ionskih kanala u nastanku bolnih stanja kraniofacijalnih struktura. Ionski kanali svoju ulogu ostvaruju kroz regulaciju podražljivosti neurona. S obzirom na to da se senzorički podražaj iz kraniofacijalnog područja prenosi preko neurona trigeminalnog ganglija (TRG) u više moždane centre odgovorne za bol, promjene u ekspresiji ionskih kanala na nivou neurona TRG-a mogući su čimbenici u nastanku TMP-a.
Abstract (English)
Temporomandibular disorders (TMDs) comprise a number of clinical conditions characterized by changes in masticatory muscles, temporomandibular joints (TMJ) and associated structures. According to researches in the U.S. and Europe, chronic orofacial pain encompasses 40 % of all chronic pain conditions, of which 10-15 % is related to the TMD. Pain and sensitivity of masticatory muscles and TMJ are most prominent symptoms of TMD. Although the etiopathogenesis of TMD has not been fully elucidated, in patients with TMD were observed changes in the processing of painful stimuli, indicating the importance of ion channels in the development of craniofacial painful conditions. Ion channels seam to regulate neuronal excitability. Since sensory inputs from craniofacial region are transmitted to higher neural centers responsible for pain sensations through trigeminal ganglion (TRG) neurons, changes in expression of various ion channels in TRG neurons might be causative in development of TMD.
Keywords (Croatian)ionski kanali temporomandibularni poremećaj trigeminalni ganglij
Keywords (English)ion channels temporomandibular disorders trigeminal ganglion
Publication typeprofessional paper - review paper
Publication statuspublished
Peer reviewpeer review
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numbering2013, Vol. 49, No. 1, pp 57-61
ISSN0025-7729
Datepublication: 04.03.2013.
Article URLhttp://hrcak.srce.hr/98610
Scientific fieldBIOMEDICINE AND HEALTHCARE
Dental Medicine
Prosthetic Dentistry
InstitutionUniversity of Rijeka, Faculty of Medicine
(Department of Prosthodontics)
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:610071