prikaz prve stranice dokumenta Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
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Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
Journal of Experimental Medicine, 222 (2025), 3; e20240930. https://doi.org/10.1084/jem.20240930
Sparano, Colin; Solís-Sayago, Darío; Zangger, Nathan Sébastien; Rindlisbacher, Lukas; Van Hove, Hannah; Vermeer, Marijne; Westermann, Frederike; Mussak, Caroline; Rallo, Elisa; Dergun, Stanislav; Litscher, Gioana; Xu, Yishu; Bijnen, Mitchell; Friedrich, Christin; Greter, Melanie; Juranić Lisnić, Vanda; Becher, Burkhard; Gasteiger, Georg; Oxenius, Annette; Tugues, Sonia Više autora...

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Sparano, C., Solís Sayago, D., Zangger, N. S., Rindlisbacher, L., Van Hove, H., Vermeer, M. ... Tugues, S. (2025). Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells. Journal of Experimental Medicine, 222. (3). doi: 10.1084/jem.20240930

Sparano, Colin, et al. "Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells." Journal of Experimental Medicine, vol. 222, br. 3, 2025. https://doi.org/10.1084/jem.20240930

Sparano, Colin, Darío Solís Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, et al. "Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells." Journal of Experimental Medicine 222, br. 3 (2025). https://doi.org/10.1084/jem.20240930

Sparano, C., et al. (2025) 'Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells', Journal of Experimental Medicine, 222(3). doi: 10.1084/jem.20240930

Sparano C, Solís Sayago D, Zangger NS, Rindlisbacher L, Van Hove H, Vermeer M, i sur.. Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells. Journal of Experimental Medicine [Internet]. 03.03.2025. [pristupljeno 11.03.2025.];222(3). doi: 10.1084/jem.20240930

C. Sparano, et al., "Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells", Journal of Experimental Medicine, vol. 222, br. 3, Ožujak 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:591860. [Citirano: 11.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:591860
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Naslov (engleski)Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
AutorColin Sparano
AutorDarío Solís-Sayago
AutorNathan Sébastien Zangger
AutorLukas Rindlisbacher
AutorHannah Van Hove
AutorMarijne Vermeer
AutorFrederike Westermann
AutorCaroline Mussak
AutorElisa Rallo
AutorStanislav Dergun
AutorGioana Litscher
AutorYishu Xu
AutorMitchell Bijnen
AutorChristin Friedrich
AutorMelanie Greter
AutorVanda Juranić Lisnić
AutorBurkhard Becher
AutorGeorg Gasteiger
AutorAnnette Oxenius
AutorSonia Tugues
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, and regulate the conversion of NK cells into tissue-resident NK (trNK) cells are currently not well understood. Here, we identify autocrine transforming growth factor-β (TGF-β) as a cell-autonomous driver for NK cell tissue residency across multiple glandular tissues during development. Cell-intrinsic production of TGF-β was continuously required for the maintenance of trNK cells and synergized with Hobit to enhance cytotoxic function. Whereas autocrine TGF-β was redundant in tumors, our study revealed that NK cell–derived TGF-β allowed the expansion of cytotoxic trNK cells during local infection with murine cytomegalovirus (MCMV) and contributed to viral control in the salivary gland. Collectively, our findings reveal tissue-specific regulation of trNK cell differentiation and function by autocrine TGF-β1, which is relevant for antiviral immunity.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 222, br. 3, e20240930
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20240930
URN:NBNurn:nbn:hr:184:591860
Datum objave publikacije2025-03-03
URL dokumentahttps://rupress.org/jem/article/222/3/e20240930/277170/Autocrine-TGF-1-drives-tissue-specific
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
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Datum i vrijeme pohrane2025-03-11 09:02:23