Repozitorij MEDRI
| Naslov (engleski) | Quantitative and qualitative variations of TILs in risk stratification and patient selection for neoadjuvant chemotherapy of luminal B and triple negative breast cancer immunophenotype |
| Autor | Manuela Avirović Sveučilište u Rijeci, Medicinski fakultet |
| Suradnik | Ana Car Peterko (Other) KBC Rijeka; Medicinski fakultet Sveučilište u Rijeci |
| Znanstveno / umjetničko područje, polje i grana | BIOMEDICINA I ZDRAVSTVO Kliničke medicinske znanosti Patologija |
| Sažetak (engleski) | Luminal B breast cancer (LBBC) represents an aggressive, high-grade ER+ disease, associated with a high proliferation rate of tumor cells, higher mutation burden and higher probability of eliciting the immune response. Clinical and pathological data from 89 patients of stage II-III, triple-negative(TN) and luminal B-like BC(LB-like BC) were included in the analysis. All patients were submitted to neoadjuvant chemotherapy (NACT). Quantitative and qualitative evaluation of TILs was performed on tissue microarrays constructed from pretreatment core-needle biopsy tumor specimens. The proportion of stromal TILs, CD8, CD4 and PD-L1 positive(+) immune cells (IC), as well as the number of FOXP3, CTLA4 and HSP-70+IC was observed concerning tumor immunophenotype, traditional clinicopathological prognostic factors and tumor response to NACT. There was no statistically significant difference in the proportion of stromal TILs between LB-like and TNBC (P=0.344) cohorts. However, a higher CD4/CD8 ratio was associated with the TNBC biology (P=0.018) and within the LB-like BC cohort with high proliferation index and metastatic nodal involvement (P=0.045, P=0.015). Within the LB-like BC cohort, a higher expression of PD-L1 and HSP70+IC was associated with high proliferation index of tumor cells (P=0.018, P=0.040), massive metastatic nodal involvement (P=0.002, P=0.026) and higher stages of disease (P=0.004, P=0.042). Better response to NACT was associated with higher number of HSP70+IC and a higher proportion of CD8+ cells within LB-like BC cohort (P=0.045, P=0.012). Routine evaluation of immune markers and HSP70 may help identify high-risk patients of LB-like breast cancer who would have a better response to NACT. |
| Metodologija (hrvatski) | Nakon što se pregledom informatičkih baza podataka, Vegasoft i IBIS, pronađu slučajevi prema uključnim kriterijima istraživanja, sirovi podaci se pohranjuju na odvojenu i zaštićenu lokaciju od lokacije radnih verzija istraživačkih podataka. Podaci će se obraditi i pripremiti za statističku analizu. |
| Ključne riječi (hrvatski) | |
| Jezik | hrvatski |
| URN:NBN | urn:nbn:hr:184:637606 |
| Datum objave | 2025-01-20 |
| Geolokacija | Braće Branchetta 20, Rijeka, Hrvatska |
| Projekt | Šifra: uniri-biomed-18-259 1428 Naziv (hrvatski): Predictive and prognostic role of immune system cells, PD-1, PDL-1 and heat shock proteins in patients with triple negative, HER-2 positive and neoadjuvant treated breast cancer Kratica: uniri-biomed-18-259 1428 Voditelj: Manuela Avirović |
| Izdavač | Medicinski fakultet Faculty of Medicine |
| Prava pristupa | Zatvoreni pristup |
| Uvjeti korištenja |  |
| Datum i vrijeme pohrane | 2025-01-19 06:59:29 |
