prikaz prve stranice dokumenta Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment
  Preuzmi
PDF 1008.17 KB
Znanstveni rad - Izvorni znanstveni rad
Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment
International Journal of Molecular Sciences, 25 (2024), 22; 12103. https://doi.org/10.3390/ijms252212103
Mujić Franić, Aida; Lilić, Marko; Katalinić, Nataša; Glavaš-Obrovac, Ljubica

Citirajte ovaj rad

Mujić Franić, A., Lilić, M., Katalinić, N. i Glavaš Obrovac, Lj. (2024). Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment. International Journal of Molecular Sciences, 25. (22). doi: 10.3390/ijms252212103

Mujić Franić, Aida, et al. "Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment." International Journal of Molecular Sciences, vol. 25, br. 22, 2024. https://doi.org/10.3390/ijms252212103

Mujić Franić, Aida, Marko Lilić, Nataša Katalinić i Ljubica Glavaš Obrovac. "Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment." International Journal of Molecular Sciences 25, br. 22 (2024). https://doi.org/10.3390/ijms252212103

Mujić Franić, A., et al. (2024) 'Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment', International Journal of Molecular Sciences, 25(22). doi: 10.3390/ijms252212103

Mujić Franić A, Lilić M, Katalinić N, Glavaš Obrovac Lj. Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment. International Journal of Molecular Sciences [Internet]. 11.11.2024. [pristupljeno 02.12.2024.];25(22). doi: 10.3390/ijms252212103

A. Mujić Franić, M. Lilić, N. Katalinić i Lj. Glavaš Obrovac, "Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment", International Journal of Molecular Sciences, vol. 25, br. 22, Studeni 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:977560. [Citirano: 02.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:977560
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment
AutorAida Mujić Franić
AutorMarko Lilić
AutorNataša Katalinić
AutorLjubica Glavaš-Obrovac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička imunologija
Sažetak (engleski)
Alloimmunization remains a major obstacle to successful kidney transplantation, mainly due to the formation of anti-HLA antibodies. In recent years, non-HLA antibodies have emerged as additional immunologic factors that can potentially contribute to graft rejection. The aim of this study was to investigate the prevalence and specificity of both anti-HLA and non-HLA antibodies in patients with end-stage renal disease on a waiting list for kidney transplantation. Serum samples from 74 patients were analyzed using complement-dependent cytotoxicity and solid-phase assays. IgG anti-HLA antibodies were identified in 43.2% of participants, while IgG non-HLA antibodies were detected in 91.9%. The most frequent non-HLA antibodies included anti-ENO1 (28.4%), anti-FIBR1 (23.0%) and anti-PRKCZ (23.0%). A significant difference was found between the number of distinct IgG anti-HLA and IgG non-HLA antibody specificities. However, no significant correlation was found between the number of IgG non-HLA antibody specificities and previous alloimmunization events or dialysis treatments. These results suggest that non-HLA antibodies, although often overlooked, can sometimes play a critical role in transplant outcomes. Routine testing for non-HLA antibodies, in addition to mandatory anti-HLA antibody screening and identification, could improve immunologic risk assessment in transplant patients and post-transplant care.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 22, 12103
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252212103
URN:NBNurn:nbn:hr:184:977560
Datum objave publikacije2024-11-11
URL dokumentahttps://www.mdpi.com/1422-0067/25/22/12103
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-11-13 12:05:55