prikaz prve stranice dokumenta Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development
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Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development
JCI Insight, 9 (2024), 11; e175525.. https://doi.org/10.1172/jci.insight.175525
Sung, Cathy Yea Won; Li, Mao; Jonjić, Stipan; Sanchez, Veronica; Britt, William J.

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Sung, C. Y. W., Li, M., Jonjić, S., Sanchez, V. i Britt, W. J. (2024). Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development. JCI Insight, 9. (11). doi: 10.1172/jci.insight.175525

Sung, Cathy Yea Won, et al. "Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development." JCI Insight, vol. 9, br. 11, 2024. https://doi.org/10.1172/jci.insight.175525

Sung, Cathy Yea Won, Mao Li, Stipan Jonjić, Veronica Sanchez i William J. Britt. "Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development." JCI Insight 9, br. 11 (2024). https://doi.org/10.1172/jci.insight.175525

Sung, C. Y. W., et al. (2024) 'Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development', JCI Insight, 9(11). doi: 10.1172/jci.insight.175525

Sung CYW, Li M, Jonjić S, Sanchez V, Britt WJ. Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development. JCI Insight [Internet]. 10.06.2024. [pristupljeno 11.11.2024.];9(11). doi: 10.1172/jci.insight.175525

C. Y. W. Sung, M. Li, S. Jonjić, V. Sanchez i W. J. Britt, "Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development", JCI Insight, vol. 9, br. 11, Lipanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:098595. [Citirano: 11.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:098595
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Naslov (engleski)Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development
AutorCathy Yea Won Sung
AutorMao Li
AutorStipan Jonjić
AutorVeronica Sanchez
AutorWilliam J. Britt
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human cytomegalovirus (HCMV) infection in infants infected in utero can lead to a variety of neurodevelopmental disorders. However, mechanisms underlying altered neurodevelopment in infected infants remain poorly understood. We have previously described a murine model of congenital HCMV infection in which murine CMV (MCMV) spreads hematogenously and establishes a focal infection in all regions of the brain of newborn mice, including the cerebellum. Infection resulted in disruption of cerebellar cortical development characterized by reduced cerebellar size and foliation. This disruption was associated with altered cell cycle progression of the granule cell precursors (GCPs), which are the progenitors that give rise to granule cells (GCs), the most abundant neurons in the cerebellum. In the current study, we have demonstrated that MCMV infection leads to prolonged GCP cell cycle, premature exit from the cell cycle, and reduced numbers of GCs resulting in cerebellar hypoplasia. Treatment with TNF-α neutralizing antibody partially normalized the cell cycle alterations of GCPs and altered cerebellar morphogenesis induced by MCMV infection. Collectively, our results argue that virus-induced inflammation altered the cell cycle of GCPs resulting in a reduced numbers of GCs and cerebellar cortical hypoplasia, thus providing a potential mechanism for altered neurodevelopment in fetuses infected with HCMV.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJCI Insight
Brojčani podacivol. 9, br. 11, e175525.
e-ISSN2379-3708
DOIhttps://doi.org/10.1172/jci.insight.175525
URN:NBNurn:nbn:hr:184:098595
Datum objave publikacije2024-06-10
URL dokumentahttps://insight.jci.org/articles/view/175525
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-11-11 13:27:00