prikaz prve stranice dokumenta The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections
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The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections
International Journal of Molecular Sciences, 25 (2024), 20; 10891. https://doi.org/10.3390/ijms252010891
Ćurko-Cofek, Božena; Jenko, Matej; Taleska Stupica, Gordana; Batičić, Lara; Krsek, Antea; Batinac, Tanja; Ljubačev, Aleksandra; Zdravković, Marko; Knežević, Danijel; Šoštarič, Maja; Sotošek, Vlatka

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Ćurko Cofek, B., Jenko, M., Taleska Stupica, G., Batičić, L., Krsek, A., Batinac, T. ... Sotošek, V. (2024). The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections. International Journal of Molecular Sciences, 25. (20). doi: 10.3390/ijms252010891

Ćurko Cofek, Božena, et al. "The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections." International Journal of Molecular Sciences, vol. 25, br. 20, 2024. https://doi.org/10.3390/ijms252010891

Ćurko Cofek, Božena, Matej Jenko, Gordana Taleska Stupica, Lara Batičić, Antea Krsek, Tanja Batinac, Aleksandra Ljubačev, et al. "The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections." International Journal of Molecular Sciences 25, br. 20 (2024). https://doi.org/10.3390/ijms252010891

Ćurko Cofek, B., et al. (2024) 'The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections', International Journal of Molecular Sciences, 25(20). doi: 10.3390/ijms252010891

Ćurko Cofek B, Jenko M, Taleska Stupica G, Batičić L, Krsek A, Batinac T, i sur.. The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections. International Journal of Molecular Sciences [Internet]. 10.10.2024. [pristupljeno 04.12.2024.];25(20). doi: 10.3390/ijms252010891

B. Ćurko Cofek, et al., "The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections", International Journal of Molecular Sciences, vol. 25, br. 20, Listopad 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:543128. [Citirano: 04.12.2024.]

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Podaci o radu
Naslov (engleski)The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery—Exploring the Molecular Connections
AutorBožena Ćurko-Cofek
AutorMatej Jenko
AutorGordana Taleska Stupica
AutorLara Batičić
AutorAntea Krsek
AutorTanja Batinac
AutorAleksandra Ljubačev
AutorMarko Zdravković
AutorDanijel Knežević
AutorMaja Šoštarič
AutorVlatka Sotošek
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Since its introduction, the number of heart surgeries has risen continuously. It is a high-risk procedure, usually involving cardiopulmonary bypass, which is associated with an inflammatory reaction that can lead to perioperative and postoperative organ dysfunction. The extent of complications following cardiac surgery has been the focus of interest for several years because of their impact on patient outcomes. Recently, numerous scientific efforts have been made to uncover the complex mechanisms of interaction between inflammation, oxidative stress, and endothelial dysfunction that occur after cardiac surgery. Numerous factors, such as surgical and anesthetic techniques, hypervolemia and hypovolemia, hypothermia, and various drugs used during cardiac surgery trigger the development of systemic inflammatory response and the release of oxidative species. They affect the endothelium, especially endothelial glycocalyx (EG), a thin surface endothelial layer responsible for vascular hemostasis, its permeability and the interaction between leukocytes and endothelium. This review highlights the current knowledge of the molecular mechanisms involved in endothelial dysfunction, particularly in the degradation of EG. In addition, the major inflammatory events and oxidative stress responses that occur in cardiac surgery, their interaction with EG, and the clinical implications of these events have been summarized and discussed in detail. A better understanding of the complex molecular mechanisms underlying cardiac surgery, leading to endothelial dysfunction, is needed to improve patient management during and after surgery and to develop effective strategies to prevent adverse outcomes that complicate recovery.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 20, 10891
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252010891
URN:NBNurn:nbn:hr:184:543128
Datum objave publikacije2024-10-10
ProjektŠifra: IPS-2023-02-9650
Naziv (hrvatski): Endotelna disfunkcija, upala i oksidacijski stres u kardiokirurških bolesnika
Naziv (engleski): Endothelial dysfunction, inflammation and oxidative stress in patients undergoing cardiac surgery
Kratica: EDIOS
Voditelj: Vlatka Sotošek Tokmadžić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/1422-0067/25/20/10891
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-10-11 06:51:39