prikaz prve stranice dokumenta Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis
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Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis
Journal of Functional Biomaterials, 15 (2024), 9; 270. https://doi.org/10.3390/jfb15090270
Čandrlić, Marija; Jerbić Radetić, Ana Terezija; Omrčen, Hrvoje; Franović, Barbara; Batičić, Lara; Gulić, Tamara; Čaljkušić-Mance, Tea; Zoričić Cvek, Sanja; Malešić, Lucija; Perić Kačarević, Željka; Cvijanović Peloza, Olga

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Čandrlić, M., Jerbić Radetić, A. T., Omrčen, H., Franović, B., Batičić, L., Gulić, T. ... Cvijanović Peloza, O. (2024). Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis. Journal of Functional Biomaterials, 15. (9). doi: 10.3390/jfb15090270

Čandrlić, Marija, et al. "Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis." Journal of Functional Biomaterials, vol. 15, br. 9, 2024. https://doi.org/10.3390/jfb15090270

Čandrlić, Marija, Ana Terezija Jerbić Radetić, Hrvoje Omrčen, Barbara Franović, Lara Batičić, Tamara Gulić, Tea Čaljkušić Mance, et al. "Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis." Journal of Functional Biomaterials 15, br. 9 (2024). https://doi.org/10.3390/jfb15090270

Čandrlić, M., et al. (2024) 'Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis', Journal of Functional Biomaterials, 15(9). doi: 10.3390/jfb15090270

Čandrlić M, Jerbić Radetić AT, Omrčen H, Franović B, Batičić L, Gulić T, i sur.. Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis. Journal of Functional Biomaterials [Internet]. 18.09.2024. [pristupljeno 03.12.2024.];15(9). doi: 10.3390/jfb15090270

M. Čandrlić, et al., "Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis", Journal of Functional Biomaterials, vol. 15, br. 9, Rujan 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:225078. [Citirano: 03.12.2024.]

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Naslov (engleski)Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis
AutorMarija Čandrlić
AutorAna Terezija Jerbić Radetić
AutorHrvoje Omrčen
AutorBarbara Franović
AutorLara Batičić
AutorTamara Gulić
AutorTea Čaljkušić-Mance
AutorSanja Zoričić Cvek
AutorLucija Malešić
AutorŽeljka Perić Kačarević
AutorOlga Cvijanović Peloza
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The aim of this study was to evaluate the efficacy of autologous dentin (AD), bovine xenograft (BX) and magnesium-enriched bovine xenograft (BX + Mg) in the healing of critical cranial bone defects (CCBDs) in rats. Eighty male Wistar rats were divided into four groups: BX, BX + Mg, AD and the control group (no intervention). Eight mm CCBDs were created and treated with the respective biomaterials. Healing was assessed 7, 15, 21 and 30 days after surgery by micro-computed tomography (micro-CT), real-time polymerase chain reaction (RT-PCR) and immunohistochemical analysis. Micro-CT analysis showed that AD had the highest bone volume and the least amount of residual biomaterial at day 30, indicating robust bone formation and efficient resorption. BX + Mg showed significant bone volume but had more residual biomaterial compared to AD. RT-PCR showed that the expression of osteocalcin (OC), the receptor activator of nuclear factor κB (RANK) and sclerostin (SOST), was highest in the AD group at day 21 and vascular endothelial growth factor (VEGF) at day 15, indicating increased osteogenesis and angiogenesis in the AD group. Immunohistochemical staining confirmed intense BMP-2/4 and SMAD-1/5/8 expression in the AD group, indicating osteoinductive properties. The favorable gene expression profile and biocompatibility of AD and BX + Mg make them promising candidates for clinical applications in bone tissue engineering. Further research is required to fully exploit their potential in regenerative surgery.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Functional Biomaterials
Brojčani podacivol. 15, br. 9, 270
e-ISSN2079-4983
DOIhttps://doi.org/10.3390/jfb15090270
URN:NBNurn:nbn:hr:184:225078
Datum objave publikacije2024-09-18
ProjektŠifra: IP-2020-02-7875
Naziv (hrvatski): Usporedba reparacijskog odgovora koštanog tkiva upotrebom dentina, ksenogenog biomaterijala i autologne kosti
Naziv (engleski): Comparison of the repair of bone tissue response using dentin, xenogeneic biomaterial and autologous bone
Kratica: MgXBiomBone
Voditelj: Olga Cvijanović Peloza
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/2079-4983/15/9/270
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-19 06:43:21