prikaz prve stranice dokumenta Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels
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Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels
Environmental Research, 260 (2024); 119583. https://doi.org/10.1016/j.envres.2024.119583
Palir, Neža; Stajnko, Anja; Mazej, Darja; France Štiglic, Alenka; Rosolen, Valentina; Mariuz, Marika; Ronfani, Luca; Snoj Tratnik, Janja; Runkel, Agneta Annika; Tursunova, Veronika; Marc, Janja; Prpić, Igor; Špirić, Zdravko; Barbone, Fabio; Horvat, Milena; Falnoga, Ingrid Više autora...

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Palir, N., Stajnko, A., Mazej, D., France Štiglic, A., Rosolen, V., Mariuz, M. ... Falnoga, I. (2024). Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels. Environmental Research, 260.. doi: 10.1016/j.envres.2024.119583

Palir, Neža, et al. "Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels." Environmental Research, vol. 260, 2024. https://doi.org/10.1016/j.envres.2024.119583

Palir, Neža, Anja Stajnko, Darja Mazej, Alenka France Štiglic, Valentina Rosolen, Marika Mariuz, Luca Ronfani, et al. "Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels." Environmental Research 260 (2024). https://doi.org/10.1016/j.envres.2024.119583

Palir, N., et al. (2024) 'Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels', Environmental Research, 260. doi: 10.1016/j.envres.2024.119583

Palir N, Stajnko A, Mazej D, France Štiglic A, Rosolen V, Mariuz M, i sur.. Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels. Environmental Research [Internet]. 11.2024. [pristupljeno 25.12.2024.];260. doi: 10.1016/j.envres.2024.119583

N. Palir, et al., "Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels", Environmental Research, vol. 260, Studeni 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:711087. [Citirano: 25.12.2024.]

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Naslov (engleski)Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels
AutorNeža Palir
AutorAnja Stajnko
AutorDarja Mazej
AutorAlenka France Štiglic
AutorValentina Rosolen
AutorMarika Mariuz
AutorLuca Ronfani
AutorJanja Snoj Tratnik
AutorAgneta Annika Runkel
AutorVeronika Tursunova
AutorJanja Marc
AutorIgor Prpić
AutorZdravko Špirić
AutorFabio Barbone
AutorMilena Horvat
AutorIngrid Falnoga
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za pedijatriju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ε2, ε3, ε4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay among maternal APOE (mAPOE) genotypes, fetal sex, parity, and Pb in maternal and cord blood (mB-Pb, CB-Pb) using linear regression models. Our study involved 817 pregnant women and 772 newborns with measured adequate levels of zinc and selenium. We compared carriers of the ε2 and ε4 alleles to those with the ε3/ε3 genotype. The geometric means (range) of mB-Pb and CB-Pb were 11.1 (3.58–87.6) and 9.31 (1.82–47.0) ng/g, respectively. In cases with female fetuses, the maternal mAPOE ε2 allele was associated with higher, while the mAPOE ε4 allele was associated with lower mB-Pb and CB-Pb levels. Nulliparity increased the strength of the observed associations. These findings highlight the significance of mAPOE genetics, fetal sex, and parity in prenatal Pb kinetics. Notably, the maternal ε2 allele may increase the risk of Pb exposure.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEnvironmental Research
Brojčani podacivol. 260, 119583
p-ISSN0013-9351
DOIhttps://doi.org/10.1016/j.envres.2024.119583
URN:NBNurn:nbn:hr:184:711087
Datum objave publikacije2024-11
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0013935124014889
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-08-14 10:17:16