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Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications
Journal of Clinical Medicine, 13 (2024), 15; 4459. https://doi.org/10.3390/jcm13154459
Krečak, Ivan; Leković, Danijela; Arsenovic, Isidora; Bogdanović, Andrija; Holik, Hrvoje; Zekanović, Ivan; Morić Perić, Martina; Lucijanić, Marko

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Krečak, I., Leković, D., Arsenovic, I., Bogdanović, A., Holik, H., Zekanović, I. ... Lucijanić, M. (2024). Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications. Journal of Clinical Medicine, 13. (15). doi: 10.3390/jcm13154459

Krečak, Ivan, et al. "Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications." Journal of Clinical Medicine, vol. 13, br. 15, 2024. https://doi.org/10.3390/jcm13154459

Krečak, Ivan, Danijela Leković, Isidora Arsenovic, Andrija Bogdanović, Hrvoje Holik, Ivan Zekanović, Martina Morić Perić i Marko Lucijanić. "Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications." Journal of Clinical Medicine 13, br. 15 (2024). https://doi.org/10.3390/jcm13154459

Krečak, I., et al. (2024) 'Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications', Journal of Clinical Medicine, 13(15). doi: 10.3390/jcm13154459

Krečak I, Leković D, Arsenovic I, Bogdanović A, Holik H, Zekanović I, i sur.. Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications. Journal of Clinical Medicine [Internet]. 30.07.2024. [pristupljeno 19.03.2025.];13(15). doi: 10.3390/jcm13154459

I. Krečak, et al., "Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications", Journal of Clinical Medicine, vol. 13, br. 15, Srpanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:203729. [Citirano: 19.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:203729
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Naslov (engleski)Systemic Inflammatory Index in Polycythemia Vera and Its Prognostic Implications
AutorIvan Krečak
AutorDanijela Leković
AutorIsidora Arsenovic
AutorAndrija Bogdanović
AutorHrvoje Holik
AutorIvan Zekanović
AutorMartina Morić Perić
AutorMarko Lucijanić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: This study aimed to evaluate the clinical and prognostic associations of the systemic inflammatory index (SII) in polycythemia vera (PV) patients. SII integrates information on absolute neutrophil (ANC), lymphocyte (ALC), and platelet counts into one index (calculated as ANCxALC/platelet count) and was previously shown to predict thrombotic and mortality risks in the general population. Methods: A total of 279 PV patients treated in several hematologic centers in Croatia and Serbia... Više was retrospectively evaluated. Results: The median SII for the overall cohort was 1960. Higher SII stratified at the specific cut-off points was significantly associated with shorter time to thrombosis (TTT; p = 0.004) driven by arterial thrombotic events, and shorter overall survival (OS; p < 0.001). Higher SII was able to refine the European Leukemia Net-defined high-risk patient subgroup for both thrombotic and survival risks, especially in individuals over 60 years of age. SII and all other evaluated CBC components and indices (leukocytes, ANC, ALC, platelets, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)) demonstrated low-to-modest prognostic properties, whereas SII outperformed other parameters with respect to TTT and OS prognostications. Discussion: The presented results complement prior studies evaluating the prognostic performance of different CBC components for thrombotic and survival risk predictions and offer more options to personalize PV treatments. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 13, br. 15, 4459
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm13154459
URN:NBNurn:nbn:hr:184:203729
Datum objave publikacije2024-07-30
URL dokumentahttps://www.mdpi.com/2077-0383/13/15/4459
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-08-06 11:35:11
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