PWS is a complex genetic disorder caused by the loss of function of paternal genes on chromosome 15q11-q13, leading to profound hypothalamic dysfunction. This overview thesis examines the endocrinological peculiarities associated with PWS, focusing on the multifaceted hormonal imbalances and their clinical manifestations. Key endocrine issues include growth hormone deficiency, hypogonadism, hypothyroidism, hyperphagia, obesity, insulin resistance, and adrenal insufficiency. Growth hormone deficiency contributes to short stature, reduced muscle mass, and increased adiposity, while hypogonadism results in delayed or incomplete puberty and infertility. Hypothyroidism exacerbates metabolic challenges, and hyperphagia drives severe obesity, necessitating stringent management strategies. Insulin resistance heightens the risk of type 2 diabetes, and adrenal insufficiency, though less common, poses additional health risks. This thesis underscores the critical role of early diagnosis and comprehensive, multidisciplinary management in optimizing growth, development, and metabolic health in individuals with PWS.