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Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis
Life, 14 (2024), 4; 523. https://doi.org/10.3390/life14040523
Lucijanić, Marko; Krečak, Ivan; Sorić, Ena; Sabljić, Anica; Galušić, Davor; Holik, Hrvoje; Periša, Vlatka; Morić Perić, Martina; Zekanović, Ivan; Budimir, Josipa; Kušec, Rajko

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Lucijanić, M., Krečak, I., Sorić, E., Sabljić, A., Galušić, D., Holik, H. ... Kušec, R. (2024). Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis. Life, 14. (4). doi: 10.3390/life14040523

Lucijanić, Marko, et al. "Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis." Life, vol. 14, br. 4, 2024. https://doi.org/10.3390/life14040523

Lucijanić, Marko, Ivan Krečak, Ena Sorić, Anica Sabljić, Davor Galušić, Hrvoje Holik, Vlatka Periša, et al. "Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis." Life 14, br. 4 (2024). https://doi.org/10.3390/life14040523

Lucijanić, M., et al. (2024) 'Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis', Life, 14(4). doi: 10.3390/life14040523

Lucijanić M, Krečak I, Sorić E, Sabljić A, Galušić D, Holik H, i sur.. Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis. Life [Internet]. 17.04.2024. [pristupljeno 07.05.2024.];14(4). doi: 10.3390/life14040523

M. Lucijanić, et al., "Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis", Life, vol. 14, br. 4, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:490330. [Citirano: 07.05.2024.]

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Podaci o radu
Naslov (engleski)Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis
AutorMarko Lucijanić
AutorIvan Krečak
AutorEna Sorić
AutorAnica Sabljić
AutorDavor Galušić
AutorHrvoje Holik
AutorVlatka Periša
AutorMartina Morić Perić
AutorIvan Zekanović
AutorJosipa Budimir
AutorRajko Kušec
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aim: To investigate the prognostic contribution of absolute neutrophil (ANC), lymphocyte (ALC), platelet count and their ratios, neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR), to thrombotic risk in patients with prefibrotic and overt fibrotic myelofibrosis (MF). Methods: We retrospectively analyzed a cohort of 256 patients with prefibrotic (85 patients) and overt fibrotic MF (171 patients) treated in six Croatian hematological centers. Results: Prefibrotic compared to overt fibrotic MF patients presented with significantly higher ALC, platelet count and PLR, and experienced longer time to thrombosis (TTT). Among prefibrotic patients, ANC > 8.33 × 109/L (HR 13.08, p = 0.036), ALC > 2.58 × 109/L (HR 20.63, p = 0.049) and platelet count > 752 × 109/L (HR 10.5, p = 0.043) remained independently associated with shorter TTT. Among overt fibrotic patients, ANC > 8.8 × 109/L (HR 4.49, p = 0.004), ALC ≤ 1.43 × 109/L (HR 4.15, p = 0.003), platelet count ≤ 385 × 109/L (HR 4.68, p = 0.004) and chronic kidney disease (HR 9.07, p < 0.001) remained independently associated with shorter TTT. Conclusions: Prognostic properties of ANC, ALC and platelet count are mutually independent and exceed those of NLR and PLR regarding thrombotic risk stratification. ALC and platelet count associate in opposite directions with thrombotic risk in prefibrotic and overt fibrotic MF patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 14, br. 4, 523
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life14040523
URN:NBNurn:nbn:hr:184:490330
Datum objave publikacije2024-04-17
URL dokumentahttps://www.mdpi.com/2075-1729/14/4/523
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-04-18 08:36:27