prikaz prve stranice dokumenta Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro
  Preuzmi
PDF 2.38 MB
Znanstveni rad - Izvorni znanstveni rad
Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro
Cells, 13 (2024), 3; 225. https://doi.org/10.3390/cells13030225
Gržeta Krpan, Nika; Harej Hrkać, Anja; Janković, Tamara; Dolenec, Petra; Bekyarova, Elena; Parpura, Vladimir; Pilipović, Kristina

Citirajte ovaj rad

Gržeta Krpan, N., Harej Hrkać, A., Janković, T., Dolenec, P., Bekyarova, E., Parpura, V. i Pilipović, K. (2024). Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro. Cells, 13. (3). doi: 10.3390/cells13030225

Gržeta Krpan, Nika, et al. "Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro." Cells, vol. 13, br. 3, 2024. https://doi.org/10.3390/cells13030225

Gržeta Krpan, Nika, Anja Harej Hrkać, Tamara Janković, Petra Dolenec, Elena Bekyarova, Vladimir Parpura i Kristina Pilipović. "Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro." Cells 13, br. 3 (2024). https://doi.org/10.3390/cells13030225

Gržeta Krpan, N., et al. (2024) 'Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro', Cells, 13(3). doi: 10.3390/cells13030225

Gržeta Krpan N, Harej Hrkać A, Janković T, Dolenec P, Bekyarova E, Parpura V, i sur.. Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro. Cells [Internet]. 25.01.2024. [pristupljeno 13.11.2024.];13(3). doi: 10.3390/cells13030225

N. Gržeta Krpan, et al., "Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro", Cells, vol. 13, br. 3, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:201849. [Citirano: 13.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:201849
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Chemically Functionalized Single-Walled Carbon Nanotubes Prevent the Reduction in Plasmalemmal Glutamate Transporter EAAT1 Expression in, and Increase the Release of Selected Cytokines from, Stretch-Injured Astrocytes in Vitro
AutorNika Gržeta Krpan
AutorAnja Harej Hrkać
AutorTamara Janković
AutorPetra Dolenec
AutorElena Bekyarova
AutorVladimir Parpura
AutorKristina Pilipović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
We tested the effects of water-soluble single-walled carbon nanotubes, chemically functionalized with polyethylene glycol (SWCNT-PEG), on primary mouse astrocytes exposed to a severe in vitro simulated traumatic brain injury (TBI). The application of SWCNT-PEG in the culture media of injured astrocytes did not affect cell damage levels, when compared to those obtained from injured, functionalization agent (PEG)-treated cells. Furthermore, SWCNT-PEG did not change the levels of oxidatively damaged proteins in astrocytes. However, this nanomaterial prevented the reduction in plasmalemmal glutamate transporter EAAT1 expression caused by the injury, rendering the level of EAAT1 on par with that of control, uninjured PEG-treated astrocytes; in parallel, there was no significant change in the levels of GFAP. Additionally, SWCNT-PEG increased the release of selected cytokines that are generally considered to be involved in recovery processes following injuries. As a loss of EAATs has been implicated as a culprit in the suffering of human patients from TBI, the application of SWCNT-PEG could have valuable effects at the injury site, by preventing the loss of astrocytic EAAT1 and consequently allowing for a much-needed uptake of glutamate from the extracellular space, the accumulation of which leads to unwanted excitotoxicity. Additional potential therapeutic benefits could be reaped from the fact that SWCNT-PEG stimulated the release of selected cytokines from injured astrocytes, which would promote recovery after injury and thus counteract the excess of proinflammatory cytokines present in TBI.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCells
Brojčani podacivol. 13, br. 3, 225
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells13030225
URN:NBNurn:nbn:hr:184:201849
Datum objave publikacije2024-01-25
ProjektŠifra: UIP-2017-05-9517
Naziv (hrvatski): Jednozidne ugljikove nanocjevčice u eksperimentalnoj traumatskoj ozljedi mozga
Naziv (engleski): Single walled carbon nanotubes in experimental traumatic brain injury
Kratica: CarNanoTBI
Voditelj: Kristina Pilipović
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
URL dokumentahttps://www.mdpi.com/2073-4409/13/3/225
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-02-16 08:40:29