prikaz prve stranice dokumenta Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis
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Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis
International Journal of Molecular Sciences, 25 (2024), 4; 2253. https://doi.org/10.3390/ijms25042253
Laškarin, Gordana; Babarović, Emina; Kifer, Nastasia; Bulimbašić, Stela; Šestan, Mario; Held, Martina; Frković, Marijan; Gagro, Alenka; Ćorić, Marijana; Jelušić, Marija

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Laškarin, G., Babarović, E., Kifer, N., Bulimbašić, S., Šestan, M., Held, M. ... Jelušić, M. (2024). Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis. International Journal of Molecular Sciences, 25. (4). doi: 10.3390/ijms25042253

Laškarin, Gordana, et al. "Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis." International Journal of Molecular Sciences, vol. 25, br. 4, 2024. https://doi.org/10.3390/ijms25042253

Laškarin, Gordana, Emina Babarović, Nastasia Kifer, Stela Bulimbašić, Mario Šestan, Martina Held, Marijan Frković, Alenka Gagro, Marijana Ćorić i Marija Jelušić. "Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis." International Journal of Molecular Sciences 25, br. 4 (2024). https://doi.org/10.3390/ijms25042253

Laškarin, G., et al. (2024) 'Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis', International Journal of Molecular Sciences, 25(4). doi: 10.3390/ijms25042253

Laškarin G, Babarović E, Kifer N, Bulimbašić S, Šestan M, Held M, i sur.. Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis. International Journal of Molecular Sciences [Internet]. 13.02.2024. [pristupljeno 14.11.2024.];25(4). doi: 10.3390/ijms25042253

G. Laškarin, et al., "Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis", International Journal of Molecular Sciences, vol. 25, br. 4, Veljača 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:856300. [Citirano: 14.11.2024.]

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Podaci o radu
Naslov (engleski)Involvement of M1-Activated Macrophages and Perforin/Granulysin Expressing Lymphocytes in IgA Vasculitis Nephritis
AutorGordana Laškarin
AutorEmina Babarović
AutorNastasia Kifer
AutorStela Bulimbašić
AutorMario Šestan
AutorMartina Held
AutorMarijan Frković
AutorAlenka Gagro
AutorMarijana Ćorić
AutorMarija Jelušić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za rehabilitacijsku i sportsku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We investigated the polarisation of CD68+ macrophages and perforin and granulysin distributions in kidney lymphocyte subsets of children with IgA vasculitis nephritis (IgAVN). Pro-inflammatory macrophage (M)1 (CD68/iNOS) or regulatory M2 (CD68/arginase-1) polarisation; spatial arrangement of macrophages and lymphocytes; and perforin and granulysin distribution in CD3+ and CD56+ cells were visulaised using double-labelled immunofluorescence. In contrast to the tubules, iNOS+ cells were more abundant than the arginase-1+ cells in the glomeruli. CD68+ macrophage numbers fluctuated in the glomeruli and were mostly labelled with iNOS. CD68+/arginase-1+ cells are abundant in the tubules. CD56+ cells, enclosed by CD68+ cells, were more abundant in the glomeruli than in the tubuli, and co-expressed NKp44. The glomerular and interstitial/intratubular CD56+ cells express perforin and granulysin, respectively. The CD3+ cells did not express perforin, while a minority expressed granulysin. Innate immunity, represented by M1 macrophages and CD56+ cells rich in perforin and granulysin, plays a pivotal role in the acute phase of IgAVN.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 4, 2253
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25042253
URN:NBNurn:nbn:hr:184:856300
Datum objave publikacije2024-02-13
ProjektŠifra: IP-2019-04-8822
Naziv (hrvatski): Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom
Naziv (engleski): Histological, Clinical, Laboratory and Genetic Predictors of Outcome in Patients with Henoch-Schönlein Purpura and Nephritis
Kratica: PURPURAPREDICTORS
Voditelj: Marija Jelušić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/1422-0067/25/4/2253
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-02-15 08:47:08