prikaz prve stranice dokumenta Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement
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Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement
Signa Vitae, 20 (2024), 1; 35-42. https://doi.org/10.22514/sv.2024.002
Sotošek, Vlatka; Velčić Brumnjak, Sandra; Bukal, Krešimir; Papež Kinkela, Dijana; Lopac, Danijel; Gržalja, Nikola; Aralica, Merica; Batinac, Tanja; Batičić, Lara

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Sotošek, V., Velčić Brumnjak, S., Bukal, K., Papež Kinkela, D., Lopac, D., Gržalja, N. ... Batičić, L. (2024). Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement. Signa Vitae, 20. (1), 35-42. doi: 10.22514/sv.2024.002

Sotošek, Vlatka, et al. "Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement." Signa Vitae, vol. 20, br. 1, 2024, str. 35-42. https://doi.org/10.22514/sv.2024.002

Sotošek, Vlatka, Sandra Velčić Brumnjak, Krešimir Bukal, Dijana Papež Kinkela, Danijel Lopac, Nikola Gržalja, Merica Aralica, Tanja Batinac i Lara Batičić. "Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement." Signa Vitae 20, br. 1 (2024): 35-42. https://doi.org/10.22514/sv.2024.002

Sotošek, V., et al. (2024) 'Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement', Signa Vitae, 20(1), str. 35-42. doi: 10.22514/sv.2024.002

Sotošek V, Velčić Brumnjak S, Bukal K, Papež Kinkela D, Lopac D, Gržalja N, i sur.. Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement. Signa Vitae [Internet]. 2024. [pristupljeno 03.12.2024.];20(1):35-42. doi: 10.22514/sv.2024.002

V. Sotošek, et al., "Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement", Signa Vitae, vol. 20, br. 1, str. 35-42, 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:904296. [Citirano: 03.12.2024.]

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Naslov (engleski)Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement
AutorVlatka Sotošek
AutorSandra Velčić Brumnjak
AutorKrešimir Bukal
AutorDijana Papež Kinkela
AutorDanijel Lopac
AutorNikola Gržalja
AutorMerica Aralica
AutorTanja Batinac
AutorLara Batičić
Autorova ustanova(Klinički bolnički centar Rijeka)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ortopediju i fizikalnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Invasive surgical procedures cause immune system downregulation by inducing a profound proinflammatory response. Establishing the most effective type of postoperative analgesia is crucial to maintain the equilibrium of the immune system. The purpose of this research was to evaluate the influence of epidural analgesia, peripheral nerve blockade as well as systemic analgesia on stress response in patients during the early postoperative period following total knee replacement. In total, 60 patients undergoing total knee replacement were allocated into three groups (n = 20, per group) in this prospective randomized study. Group 1, Group 2 and Group 3 received epidural analgesia, sciatic and femoral peripheral nerve blocks and systemic analgesia, respectively. Intensity of pain was measured at rest and upon movement. Blood samples were collected at baseline (T0), immediately before (T1) and after (T2) surgery, and 24 (T3) and 72 (T4) h postoperatively. The absolute number of leukocytes, concentrations of catecholamine, cortisol and C-reactive protein were determined. Patients in Group 1 and Group 2 exhibited lower pain scores than Group 3. Concentrations of cortisol and norepinephrine, but not epinephrine, were significantly lower in Group 1 and Group 2 at T2 than in Group 3. Significantly lower interleukin-1β concentrations were observed in Group 1 and Group 2 at T3 and T4 than in Group 3. Interleukin-6 concentrations were minor in Group 1 and Group 2 at T2 than in Group 3. Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks are effective analgesic techniques that reduce the acute inflammatory stress response in patients during the early postoperative period following total knee replacement.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaSigna Vitae
Brojčani podacivol. 20, br. 1, str. 35-42
p-ISSN1334-5605
DOIhttps://doi.org/10.22514/sv.2024.002
URN:NBNurn:nbn:hr:184:904296
Datum objave publikacije2024
URL dokumentahttps://www.signavitae.com/articles/10.22514/sv.2024.002
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-02-13 08:42:49