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Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic
Future Pharmacology, 4 (2024), 1; 115-138. https://doi.org/10.3390/futurepharmacol4010009
Filošević Vujnović, Ana; Stanković Matić, Ivana; Saftić Martinović, Lara; Dević Pavlić, Sanja

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Filošević Vujnović, A., Stanković Matić, I., Saftić Martinović, L. i Dević Pavlić, S. (2024). Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic. Future Pharmacology, 4. (1), 115-138. doi: 10.3390/futurepharmacol4010009

Filošević Vujnović, Ana, et al. "Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic." Future Pharmacology, vol. 4, br. 1, 2024, str. 115-138. https://doi.org/10.3390/futurepharmacol4010009

Filošević Vujnović, Ana, Ivana Stanković Matić, Lara Saftić Martinović i Sanja Dević Pavlić. "Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic." Future Pharmacology 4, br. 1 (2024): 115-138. https://doi.org/10.3390/futurepharmacol4010009

Filošević Vujnović, A., et al. (2024) 'Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic', Future Pharmacology, 4(1), str. 115-138. doi: 10.3390/futurepharmacol4010009

Filošević Vujnović A, Stanković Matić I, Saftić Martinović L, Dević Pavlić S. Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic. Future Pharmacology [Internet]. 29.01.2024. [pristupljeno 15.11.2024.];4(1):115-138. doi: 10.3390/futurepharmacol4010009

A. Filošević Vujnović, I. Stanković Matić, L. Saftić Martinović i S. Dević Pavlić, "Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic", Future Pharmacology, vol. 4, br. 1, str. 115-138, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:960552. [Citirano: 15.11.2024.]

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Podaci o radu
Naslov (engleski)Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic
AutorAna Filošević Vujnović
AutorIvana Stanković Matić
AutorLara Saftić Martinović
AutorSanja Dević Pavlić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Addiction is a complex brain disease influenced by genetic, environmental, and neurological factors. Psychostimulants, cocaine, and methamphetamine influence different cell types in different brain regions, with a focus on the neurons responsible for rewarding effects in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Known markers for psychostimulant-induced neuronal plasticity in combination with droplet-based high-throughput single-cell sequencing divided the heterogeneity of cell populations in NAc and VTA into clusters, where all cells of the same type do not respond equally to exposure to psychostimulants. To explain psychostimulant-induced neuronal plasticity as changes in the amplitude and phase shifts of gene expression, we focused on epigenetic mechanisms of DNA and chromatin modifications, as well as DNA accessibility. We also comment on epitranscriptomics as a novel approach in the study of messenger RNA posttranslational modification, which regulates translation and potentially localized transcription in synapses in order to address the molecular chains that connect addiction from changes in gene expression to synaptic and, finally, neuronal plasticity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFuture Pharmacology
Brojčani podacivol. 4, br. 1, str. 115-138
e-ISSN2673-9879
DOIhttps://doi.org/10.3390/futurepharmacol4010009
URN:NBNurn:nbn:hr:184:960552
Datum objave publikacije2024-01-29
URL dokumentahttps://www.mdpi.com/2673-9879/4/1/9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-02-05 14:19:13