prikaz prve stranice dokumenta Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia
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Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia
Annals of Hepatology, 29 (2024), 1; 101156. https://doi.org/10.1016/j.aohep.2023.101156
Bubonja-Šonje, Marina; Peruč, Dolores; Abram, Maja; Mohar-Vitezić, Bojana

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Bubonja Šonje, M., Peruč, D., Abram, M. i Mohar Vitezić, B. (2024). Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia. Annals of Hepatology, 29. (1). doi: 10.1016/j.aohep.2023.101156

Bubonja Šonje, Marina, et al. "Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia." Annals of Hepatology, vol. 29, br. 1, 2024. https://doi.org/10.1016/j.aohep.2023.101156

Bubonja Šonje, Marina, Dolores Peruč, Maja Abram i Bojana Mohar Vitezić. "Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia." Annals of Hepatology 29, br. 1 (2024). https://doi.org/10.1016/j.aohep.2023.101156

Bubonja Šonje, M., et al. (2024) 'Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia', Annals of Hepatology, 29(1). doi: 10.1016/j.aohep.2023.101156

Bubonja Šonje M, Peruč D, Abram M, Mohar Vitezić B. Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia. Annals of Hepatology [Internet]. 01.2024. [pristupljeno 03.12.2024.];29(1). doi: 10.1016/j.aohep.2023.101156

M. Bubonja Šonje, D. Peruč, M. Abram i B. Mohar Vitezić, "Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia", Annals of Hepatology, vol. 29, br. 1, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:219252. [Citirano: 03.12.2024.]

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Podaci o radu
Naslov (engleski)Prevalence of occult hepatitis B virus infection and characterisation of hepatitis B surface antigen mutants among adults in western Croatia
AutorMarina Bubonja-Šonje
AutorDolores Peruč
AutorMaja Abram
AutorBojana Mohar-Vitezić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Introduction and Objectives: Occult hepatitis B virus (HBV) infection (OBI) is characterised by low levels of hepatitis B virus (HBV) DNA in the blood/liver of patients with negative hepatitis B surface antigen (HBsAg). This study aimed to determine the OBI prevalence and virological characteristics (viral genotypes and HBsAg mutants) in patients with an "anti-HBc only" serological profile. Materials and Methods: A total of 24 900 serum samples were routinely screened for hepatitis B markers over a five-year period. All anti-HBc-positive/HBsAg-negative/anti-HBs-negative sera were selected and analysed for the presence of HBV DNA. Mutational analyses of the HBs gene and polymerase gene sequences were performed. Results: 1749 (7.02%) sera were anti-HBc positive, and 113 (0.45%) sera had an "anti-HBc only" serological profile (HBsAg/anti-HBs negative). HBV DNA was detected in 12/113 (10.61%) "anti-HBc only" positive sera, representing 0.048% of all routinely tested samples. Due to extremely low viremia, HBV genome was successfully sequenced in only two sera where subgenotype D3 was confirmed. Mutational analyses of the S gene revealed multiple missense mutations. In addition to the M133I, Y134F, and G145R mutations, already associated with diagnostic escape, we also found nine novel OBI-related S-gene mutations - S136Y, F158L, K160N, E164G, S167L, A168V, L175S, S210I and F212C. Conclusions: We detected multiple known and novel S gene mutations in 2/12 (16.6%) OBI cases, nevertheless, further studies are required to determine their role in the pathogenesis of OBI. Understanding the frequencies of clinically relevant HBV mutations may contribute to improvement of diagnostic protocols.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnnals of Hepatology
Brojčani podacivol. 29, br. 1, 101156
p-ISSN1665-2681
DOIhttps://doi.org/10.1016/j.aohep.2023.101156
URN:NBNurn:nbn:hr:184:219252
Datum objave publikacije2024-01
ProjektŠifra: uniri-biomed-18-277
Naziv (hrvatski): Bakterijska patogeneza - od istraživanja do kliničke primjene
Naziv (engleski): Bacterial pathogenesis – from research to clinics
Voditelj: Maja Abram
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: uniri-biomed-18-215
Naziv (hrvatski): Proširenost i klinički značaj HBs antigenih mutanti virusa hepatitisa B
Naziv (engleski): Prevalence and clinical significance of hepatitis B surface antigen mutants
Voditelj: Marina Bubonja Šonje
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Nema
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1665268123002594
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2023-12-21 11:38:25