prikaz prve stranice dokumenta Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes
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Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes
Scandinavian Journal of Clinical and Laboratory Investigation, 83 (2023), 6; 397-402. https://doi.org/10.1080/00365513.2023.2241368
Lucijanić, Marko; Krečak, Ivan; Cicic, David; Milošević, Marko; Vukoja, Damir; Kovačević, Ivona; Marasović, Ivan; Sedinić Lacko, Martina; Baković, Josip; Jonjić, Zeljko; Vasilj, Tamara; Stojić, Josip; Atic, Armin

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Lucijanić, M., Krečak, I., Cicic, D., Milošević, M., Vukoja, D., Kovačević, I. ... Atic, A. (2023). Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes. Scandinavian Journal of Clinical and Laboratory Investigation, 83. (6), 397-402. doi: 10.1080/00365513.2023.2241368

Lucijanić, Marko, et al. "Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 83, br. 6, 2023, str. 397-402. https://doi.org/10.1080/00365513.2023.2241368

Lucijanić, Marko, Ivan Krečak, David Cicic, Marko Milošević, Damir Vukoja, Ivona Kovačević, Ivan Marasović, et al. "Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes." Scandinavian Journal of Clinical and Laboratory Investigation 83, br. 6 (2023): 397-402. https://doi.org/10.1080/00365513.2023.2241368

Lucijanić, M., et al. (2023) 'Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes', Scandinavian Journal of Clinical and Laboratory Investigation, 83(6), str. 397-402. doi: 10.1080/00365513.2023.2241368

Lucijanić M, Krečak I, Cicic D, Milošević M, Vukoja D, Kovačević I, i sur.. Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 02.08.2023. [pristupljeno 05.05.2024.];83(6):397-402. doi: 10.1080/00365513.2023.2241368

M. Lucijanić, et al., "Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes", Scandinavian Journal of Clinical and Laboratory Investigation, vol. 83, br. 6, str. 397-402, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:864292. [Citirano: 05.05.2024.]

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Naslov (engleski)Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes
AutorMarko Lucijanić
AutorIvan Krečak
AutorDavid Cicic
AutorMarko Milošević
AutorDamir Vukoja
AutorIvona Kovačević
AutorIvan Marasović
AutorMartina Sedinić Lacko
AutorJosip Baković
AutorZeljko Jonjić
AutorTamara Vasilj
AutorJosip Stojić
AutorArmin Atic
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We aimed to investigate the associations of hypo- and hyperosmolarity at hospital admission with clinical characteristics and outcomes in 5645 consecutive hospitalized COVID-19 patients treated at a tertiary-level institution. Serum osmolarity was calculated as 2x Na (mmol/L) + urea (mmol/L) + glucose (mmol/L), with normal range from 275 to 295 mOsm/L. Median serum osmolarity was 292.9 mOsm/L with 51.8% normoosmolar, 5.3% hypoosmolar and 42.9% hyperosmolar patients present at the time of hospital admission. Hypoosmolarity was driven by hyponatremia, and was associated with the presence of chronic liver disease, liver cirrhosis, active malignancy and epilepsy. Hyperosmolarity was driven by an increase in urea and glucose and was associated with the presence of chronic metabolic and cardiovascular comorbidities. Both hypo- and hyperosmolar patients presented with more severe COVID-19 symptoms, higher inflammatory status, and experienced higher mortality in comparison to normoosmolar patients. In multivariate analysis, hypoosmolarity (adjusted odds ratio (aOR)=1.39, p = 0.024) and hyperosmolarity (aOR = 1.9, p < 0.001) remained significantly associated with higher mortality independently of older age, male sex, higher Charlson Comorbidity Index and more severe COVID-19. Disruptions in serum osmolarity are frequent in COVID-19 patients, may be easy to detect and target therapeutically, and thus potentially moderate associateds poor prognosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScandinavian Journal of Clinical and Laboratory Investigation
Brojčani podacivol. 83, br. 6, str. 397-402
p-ISSN0036-5513
e-ISSN1502-7686
DOIhttps://doi.org/10.1080/00365513.2023.2241368
URN:NBNurn:nbn:hr:184:864292
Datum objave publikacije2023-08-02
URL dokumentahttps://www.tandfonline.com/doi/full/10.1080/00365513.2023.2241368
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-11-15 08:36:30