prikaz prve stranice dokumenta Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis
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Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis
Radiology and Oncology, 57 (2023), 3; 397-404. https://doi.org/10.2478/raon-2023-0040
Ljubičić, Lidija; Janzic, Urska; Unk, Mojca; Terglav, Ana Sophie; Mohorcic, Katja; Seiwerth, Fran; Bitar, Lela; Badovinac, Sonja; Pleština, Sanja; Korsic, Marta; Kukulj, Suzana; Samarzija, Miroslav; Jakopović, Marko

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Ljubičić, L., Janzic, U., Unk, M., Terglav, A. S., Mohorcic, K., Seiwerth, F. ... Jakopović, M. (2023). Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis. Radiology and Oncology, 57. (3), 397-404. doi: 10.2478/raon-2023-0040

Ljubičić, Lidija, et al. "Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis." Radiology and Oncology, vol. 57, br. 3, 2023, str. 397-404. https://doi.org/10.2478/raon-2023-0040

Ljubičić, Lidija, Urska Janzic, Mojca Unk, Ana Sophie Terglav, Katja Mohorcic, Fran Seiwerth, Lela Bitar, et al. "Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis." Radiology and Oncology 57, br. 3 (2023): 397-404. https://doi.org/10.2478/raon-2023-0040

Ljubičić, L., et al. (2023) 'Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis', Radiology and Oncology, 57(3), str. 397-404. doi: 10.2478/raon-2023-0040

Ljubičić L, Janzic U, Unk M, Terglav AS, Mohorcic K, Seiwerth F, i sur.. Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis. Radiology and Oncology [Internet]. 01.09.2023. [pristupljeno 16.04.2024.];57(3):397-404. doi: 10.2478/raon-2023-0040

L. Ljubičić, et al., "Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis", Radiology and Oncology, vol. 57, br. 3, str. 397-404, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:427998. [Citirano: 16.04.2024.]

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Naslov (engleski)Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis
AutorLidija Ljubičić
AutorUrska Janzic
AutorMojca Unk
AutorAna Sophie Terglav
AutorKatja Mohorcic
AutorFran Seiwerth
AutorLela Bitar
AutorSonja Badovinac
AutorSanja Pleština
AutorMarta Korsic
AutorSuzana Kukulj
AutorMiroslav Samarzija
AutorMarko Jakopović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Background: The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after failing ICI +/- ChT remains an open question, and docetaxel plus nintedanib represent a valid second line option. Patients and methods: A multicenter retrospective trial of real-life treatment patterns and outcomes of patients with advanced lung adenocarcinoma treated with docetaxel plus nintedanib after the failure of ICI and/or ChT was performed. Patients from 2 Slovenian and 1 Croatian oncological center treated between June 2014 and August 2022 were enrolled. We assessed objective response (ORR), disease control rate (DCR), median progression free survival (PFS), median overall survival (OS), and safety profile of treatment. Results: There were 96 patients included in the analysis, with ORR of 18.8%, DCR of 57.3%, median PFS of 3.0 months (95% CI: 3.0-5.0 months), and a median OS of 8.0 months (95% CI: 7.0-10.0 months). The majority of patients (n = 47,49%) received docetaxel plus nintedanib as third-line therapy. The ORR for this subset of patients was 19.1%, with a DCR of 57.4%. The highest response rate was observed in patients who received second-line docetaxel plus nintedanib after first-line combination of ChT-ICI therapy (n = 24), with an ORR of 29.2% and DCR of 66.7% and median PFS of 4.0 months (95% CI: 3.0-8.0 months). Fifty-three patients (55.2%) experienced adverse events (AEs), most frequently gastrointestinal; diarrhea (n = 29, 30.2%), and increased liver enzyme levels (n = 17, 17.7%). Conclusions: The combination of docetaxel and nintedanib can be considered an effective therapy option with an acceptable toxicity profile for patients with advanced NSCLC after the failure of ICI +/- ChT.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaRadiology and Oncology
Brojčani podacivol. 57, br. 3, str. 397-404
e-ISSN1581-3207
DOIhttps://doi.org/10.2478/raon-2023-0040
URN:NBNurn:nbn:hr:184:427998
Datum objave publikacije2023-09-01
URL dokumentahttps://www.sciendo.com/article/10.2478/raon-2023-0040
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-11-13 13:03:41