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HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
Journal of Virology, 97 (2023), 10; 1-21. https://doi.org/10.1128/jvi.00730-23
Zubković, Andreja; Gomes, Cristina; Parchure, Adwait; Cesarec, Mia; Ferenčić, Antun; Rokić, Filip; Jakovac, Hrvoje; Whitford, Abigail L.; Dochnal, Sara A.; Cliffe, Anna R.; Cuculić, Dražen; Gallo, Angela; Vugrek, Oliver; Hackenberg, Michael; Jurak, Igor Više autora...

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Zubković, A., Gomes, C., Parchure, A., Cesarec, M., Ferenčić, A., Rokić, F. ... Jurak, I. (2023). HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia. Journal of Virology, 97. (10), 1-21. doi: 10.1128/jvi.00730-23

Zubković, Andreja, et al. "HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia." Journal of Virology, vol. 97, br. 10, 2023, str. 1-21. https://doi.org/10.1128/jvi.00730-23

Zubković, Andreja, Cristina Gomes, Adwait Parchure, Mia Cesarec, Antun Ferenčić, Filip Rokić, Hrvoje Jakovac, et al. "HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia." Journal of Virology 97, br. 10 (2023): 1-21. https://doi.org/10.1128/jvi.00730-23

Zubković, A., et al. (2023) 'HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia', Journal of Virology, 97(10), str. 1-21. doi: 10.1128/jvi.00730-23

Zubković A, Gomes C, Parchure A, Cesarec M, Ferenčić A, Rokić F, i sur.. HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia. Journal of Virology [Internet]. 31.10.2023. [pristupljeno 08.05.2024.];97(10):1-21. doi: 10.1128/jvi.00730-23

A. Zubković, et al., "HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia", Journal of Virology, vol. 97, br. 10, str. 1-21, Listopad 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:705761. [Citirano: 08.05.2024.]

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Naslov (engleski)HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
AutorAndreja Zubković
AutorCristina Gomes
AutorAdwait Parchure
AutorMia Cesarec
AutorAntun Ferenčić
AutorFilip Rokić
AutorHrvoje Jakovac
AutorAbigail L. Whitford
AutorSara A. Dochnal
AutorAnna R. Cliffe
AutorDražen Cuculić
AutorAngela Gallo
AutorOliver Vugrek
AutorMichael Hackenberg
AutorIgor Jurak
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za sudsku medicinu i kriminalistiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Herpes simplex virus 1 is an important human pathogen that has been intensively studied for many decades. Nevertheless, the molecular mechanisms regulating its establishment, maintenance, and reactivation from latency are poorly understood. Here, we show that HSV-1-encoded miR-H2 is post-transcriptionally edited in latently infected human tissues. Hyperediting of viral miRNAs increases the targeting potential of these miRNAs and may play an important role in regulating latency. We show that the edited miR-H2 can target ICP4, an essential viral protein. Interestingly, we found no evidence of hyperediting of its homolog, miR-H2, which is expressed by the closely related virus HSV-2. The discovery of post-translational modifications of viral miRNA in the latency phase suggests that these processes may also be important for other non-coding viral RNA in the latency phase, including the intron LAT, which in turn may be crucial for understanding the biology of this virus.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Virology
Brojčani podacivol. 97, br. 10, str. 1-21
p-ISSN0022-538X
e-ISSN1098-5514
DOIhttps://doi.org/10.1128/jvi.00730-23
URN:NBNurn:nbn:hr:184:705761
Datum objave publikacije2023-10-31
ProjektŠifra: IP-2020-02-2287
Naziv (hrvatski): Uloga proteina ADAR kod infekcije herpes simpleks virusom 1
Naziv (engleski): Roles od ADAR proteins in herpes simples virus 1 infection
Kratica: eRNA-HSV-IJ
Voditelj: Igor Jurak
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://journals.asm.org/doi/10.1128/jvi.00730-23
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-11-13 12:31:27