prikaz prve stranice dokumenta Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients
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Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients
Injury, 43 (2012), 5; 624-631. https://doi.org/10.1016/j.injury.2010.05.009
Sotošek Tokmadžic, Vlatka; Laškarin, Gordana; Mahmutefendic, Hana; Lučin, Pero; Mrakovčić-Šutic, Ines; Župan, Željko; Šustić, Alan

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Sotošek Tokmadžic, V., Laškarin, G., Mahmutefendic, H., Lučin, P., Mrakovčić Šutic, I., Župan, Ž. i Šustić, A. (2012). Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients. Injury, 43. (5), 624-631. doi: 10.1016/j.injury.2010.05.009

Sotošek Tokmadžic, Vlatka, et al. "Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients." Injury, vol. 43, br. 5, 2012, str. 624-631. https://doi.org/10.1016/j.injury.2010.05.009

Sotošek Tokmadžic, Vlatka, Gordana Laškarin, Hana Mahmutefendic, Pero Lučin, Ines Mrakovčić Šutic, Željko Župan i Alan Šustić. "Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients." Injury 43, br. 5 (2012): 624-631. https://doi.org/10.1016/j.injury.2010.05.009

Sotošek Tokmadžic, V., et al. (2012) 'Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients', Injury, 43(5), str. 624-631. doi: 10.1016/j.injury.2010.05.009

Sotošek Tokmadžic V, Laškarin G, Mahmutefendic H, Lučin P, Mrakovčić Šutic I, Župan Ž, i sur.. Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients. Injury [Internet]. 2012. [pristupljeno 15.04.2024.];43(5):624-631. doi: 10.1016/j.injury.2010.05.009

V. Sotošek Tokmadžic, et al., "Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients", Injury, vol. 43, br. 5, str. 624-631, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:153525. [Citirano: 15.04.2024.]

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Podaci o radu
Naslov (engleski)Expression of cytolytic protein–perforin in peripheral blood lymphocytes in severe traumatic brain injured patients
AutorVlatka Sotošek Tokmadžic
AutorGordana Laškarin
AutorHana Mahmutefendic
AutorPero Lučin
AutorInes Mrakovčić-Šutic
AutorŽeljko Župan
AutorAlan Šustić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Anesteziologija i reanimatologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
Purpose: The purpose of this study was to investigate the changes of cytotoxic protein-perforin in peripheral blood lymphocytes in severe TBI patients and possible correlation between severity of TBI and perforin expression. Methods: Flow cytometry was used for simultaneous detection of intracellular perforin and cell surface antigens of peripheral blood lymphocytes of 20 severe TBI patients on day 1, 4 and 7 after the onset of injury. Peripheral blood mononuclear cells from 20 healthy volunteers were used as control. Clinical and laboratory parameters were also recorded. Results: There was a statistically significant decrease of perforin-positive lymphocytes including T, natural killer (NK) and NKT cells on day 4 as compared with day 1 after the brain injury or healthy controls. On day 7, perforin expression was restored in lymphocyte of cytotoxic phenotype (CD8 + T lymphocytes, NK cells, and NKT cells) compared with day 1. High positive correlation was found between the severity of TBI and frequency of perforin-positive cells on day 4 when the occurrence of the intra-hospital infections was the highest. Conclusion: Severe TBI significantly decreases perforin expression in T lymphocytes, NK and NKT cells, which indicate a possible mechanism underlying the high susceptibility to infections. © 2010 Elsevier Ltd. All rights reserved.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInjury
Brojčani podacivol. 43, br. 5, str. 624-631
p-ISSN0020-1383
DOIhttps://doi.org/10.1016/j.injury.2010.05.009
URN:NBNurn:nbn:hr:184:153525
Datum objave publikacije2012
ProjektŠifra: 062-0000000-0220
Naziv (hrvatski): Perkutana traheostomija u prevenciji pneumonije u strojno ventiliranih bolesnika
Naziv (engleski): Percutaneous tracheostomy in prevention of ventilator-associated pneumonia
Voditelj: Alan Šustić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0020138310002895
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2023-11-02 10:18:21