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Innate Immunity in Autoimmune Thyroid Disease during Pregnancy
International Journal of Molecular Sciences, 24 (2023), 20; 15442. https://doi.org/10.3390/ijms242015442
Bogović Crnčić, Tatjana; Girotto, Neva; Ilić Tomaš, Maja; Krištofić, Ines; Klobučar, Sanja; Batičić, Lara; Ćurko-Cofek, Božena; Sotošek, Vlatka

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Bogović Crnčić, T., Girotto, N., Ilić Tomaš, M., Krištofić, I., Klobučar, S., Batičić, L. ... Sotošek, V. (2023). Innate Immunity in Autoimmune Thyroid Disease during Pregnancy. International Journal of Molecular Sciences, 24. (20). doi: 10.3390/ijms242015442

Bogović Crnčić, Tatjana, et al. "Innate Immunity in Autoimmune Thyroid Disease during Pregnancy." International Journal of Molecular Sciences, vol. 24, br. 20, 2023. https://doi.org/10.3390/ijms242015442

Bogović Crnčić, Tatjana, Neva Girotto, Maja Ilić Tomaš, Ines Krištofić, Sanja Klobučar, Lara Batičić, Božena Ćurko Cofek i Vlatka Sotošek. "Innate Immunity in Autoimmune Thyroid Disease during Pregnancy." International Journal of Molecular Sciences 24, br. 20 (2023). https://doi.org/10.3390/ijms242015442

Bogović Crnčić, T., et al. (2023) 'Innate Immunity in Autoimmune Thyroid Disease during Pregnancy', International Journal of Molecular Sciences, 24(20). doi: 10.3390/ijms242015442

Bogović Crnčić T, Girotto N, Ilić Tomaš M, Krištofić I, Klobučar S, Batičić L, i sur.. Innate Immunity in Autoimmune Thyroid Disease during Pregnancy. International Journal of Molecular Sciences [Internet]. 22.10.2023. [pristupljeno 13.04.2024.];24(20). doi: 10.3390/ijms242015442

T. Bogović Crnčić, et al., "Innate Immunity in Autoimmune Thyroid Disease during Pregnancy", International Journal of Molecular Sciences, vol. 24, br. 20, Listopad 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:295340. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:295340
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Podaci o radu
Naslov (engleski)Innate Immunity in Autoimmune Thyroid Disease during Pregnancy
AutorTatjana Bogović Crnčić
AutorNeva Girotto
AutorMaja Ilić Tomaš
AutorInes Krištofić
AutorSanja Klobučar
AutorLara Batičić
AutorBožena Ćurko-Cofek
AutorVlatka Sotošek
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za nuklearnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder clinically presented as Hashimoto thyroiditis (HT) and Graves’ disease (GD). The pathogenesis of AITD is caused by an inappropriate immune response related to genetic, non-genetic, and environmental factors. Pregnancy is one of the factors that have a great influence on the function of the thyroid gland because of the increased metabolic demand and the effects of hormones related to pregnancy. During pregnancy, an adaptation of the maternal immune system occurs, especially of the innate immune system engaged in maintaining adaptive immunity in the tolerant state, preventing the rejection of the fetus. Pregnancy-related hormonal changes (estrogen, progesterone, hCG) may modulate the activity of innate immune cells, potentially worsening the course of AITD during pregnancy. This especially applies to NK cells, which are associated with exacerbation of HD and GD. On the other hand, previous thyroid disorders can affect fertility and cause adverse outcomes of pregnancy, such as placental abruption, spontaneous abortion, and premature delivery. Additionally, it can cause fetal growth retardation and may contribute to impaired neuropsychological development of the fetus. Therefore, maintaining the thyroid equilibrium in women of reproductive age and in pregnant women is of the highest importance.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 24, br. 20, 15442
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms242015442
URN:NBNurn:nbn:hr:184:295340
Datum objave publikacije2023-10-22
URL dokumentahttps://www.mdpi.com/1422-0067/24/20/15442
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-10-25 08:17:08