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Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells
Nature Communications, 14 (2023), 1; 1-17. https://doi.org/10.1038/s41467-023-42182-w
Rožmanić, Carmen; Lisnić, Berislav; Pribanić Matešić, Marina; Mihalić, Andrea; Hiršl, Lea; Park, Eugene; Lesac Brizić, Ana; Indenbirken, Daniela; Viduka, Ina; Šantić, Marina; Adler, Barbara; Yokoyama, Wayne M.; Krmpotić, Astrid; Juranić Lisnić, Vanda; Jonjić, Stipan; Brizić, Ilija Više autora...

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Rožmanić, C., Lisnić, B., Pribanić Matešić, M., Mihalić, A., Hiršl, L., Park, E. ... Brizić, I. (2023). Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nature Communications, 14. (1), 1-17. doi: 10.1038/s41467-023-42182-w

Rožmanić, Carmen, et al. "Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells." Nature Communications, vol. 14, br. 1, 2023, str. 1-17. https://doi.org/10.1038/s41467-023-42182-w

Rožmanić, Carmen, Berislav Lisnić, Marina Pribanić Matešić, Andrea Mihalić, Lea Hiršl, Eugene Park, Ana Lesac Brizić, et al. "Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells." Nature Communications 14, br. 1 (2023): 1-17. https://doi.org/10.1038/s41467-023-42182-w

Rožmanić, C., et al. (2023) 'Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells', Nature Communications, 14(1), str. 1-17. doi: 10.1038/s41467-023-42182-w

Rožmanić C, Lisnić B, Pribanić Matešić M, Mihalić A, Hiršl L, Park E, i sur.. Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nature Communications [Internet]. 12.10.2023. [pristupljeno 06.05.2024.];14(1):1-17. doi: 10.1038/s41467-023-42182-w

C. Rožmanić, et al., "Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells", Nature Communications, vol. 14, br. 1, str. 1-17, Listopad 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:168696. [Citirano: 06.05.2024.]

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Naslov (engleski)Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells
AutorCarmen Rožmanić
AutorBerislav Lisnić
AutorMarina Pribanić Matešić
AutorAndrea Mihalić
AutorLea Hiršl
AutorEugene Park
AutorAna Lesac Brizić
AutorDaniela Indenbirken
AutorIna Viduka
AutorMarina Šantić
AutorBarbara Adler
AutorWayne M. Yokoyama
AutorAstrid Krmpotić
AutorVanda Juranić Lisnić
AutorStipan Jonjić
AutorIlija Brizić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Infections in early life can elicit substantially different immune responses and pathogenesis than infections in adulthood. Here, we investigate the consequences of murine cytomegalovirus infection in newborn mice on NK cells. We show that infection severely compromised NK cell maturation and functionality in newborns. This effect was not due to compromised virus control. Inflammatory responses to infection dysregulated the expression of major transcription factors governing NK cell fate, such as Eomes, resulting in impaired NK cell function. Most prominently, NK cells from perinatally infected mice have a diminished ability to produce IFN-γ due to the downregulation of long non-coding RNA Ifng-as1 expression. Moreover, the bone marrow's capacity to efficiently generate new NK cells is reduced, explaining the prolonged negative effects of perinatal infection on NK cells. This study demonstrates that viral infections in early life can profoundly impact NK cell biology, including long-lasting impairment in NK cell functionality.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 14, br. 1, str. 1-17, 6412
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-42182-w
URN:NBNurn:nbn:hr:184:168696
Datum objave publikacije2023-10-12
ProjektŠifra: IP-2018-01-4435
Naziv (hrvatski): NK stanice u patogenezi kongenitalne infekcije citomegalovirusom
Kratica: NKconCMV
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: Nema
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
URL dokumentahttps://www.nature.com/articles/s41467-023-42182-w
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2023-10-17 11:54:35