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First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin
American Journal of Reproductive Immunology, 66 (2011), 5; 363-372. https://doi.org/10.1111/j.1600-0897.2011.01015.x
Vujaklija, Danijela Veljković; Gulić, Tamara; Sucic, Sonja; Nagata, Kinya; Ogawa, Kazuyuki; Laškarin, Gordana; Saito, Shigeru; Haller, Herman; Rukavina, Daniel

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Vujaklija, D. V., Gulić, T., Sucic, S., Nagata, K., Ogawa, K., Laškarin, G. ... Rukavina, D. (2011). First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin. American Journal of Reproductive Immunology, 66. (5), 363-372. doi: 10.1111/j.1600-0897.2011.01015.x

Vujaklija, Danijela Veljković, et al. "First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin." American Journal of Reproductive Immunology, vol. 66, br. 5, 2011, str. 363-372. https://doi.org/10.1111/j.1600-0897.2011.01015.x

Vujaklija, Danijela Veljković, Tamara Gulić, Sonja Sucic, Kinya Nagata, Kazuyuki Ogawa, Gordana Laškarin, Shigeru Saito, Herman Haller i Daniel Rukavina. "First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin." American Journal of Reproductive Immunology 66, br. 5 (2011): 363-372. https://doi.org/10.1111/j.1600-0897.2011.01015.x

Vujaklija, D. V., et al. (2011) 'First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin', American Journal of Reproductive Immunology, 66(5), str. 363-372. doi: 10.1111/j.1600-0897.2011.01015.x

Vujaklija DV, Gulić T, Sucic S, Nagata K, Ogawa K, Laškarin G, i sur.. First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin. American Journal of Reproductive Immunology [Internet]. 11.2011. [pristupljeno 05.05.2024.];66(5):363-372. doi: 10.1111/j.1600-0897.2011.01015.x

D. V. Vujaklija, et al., "First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin", American Journal of Reproductive Immunology, vol. 66, br. 5, str. 363-372, Studeni 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:738684. [Citirano: 05.05.2024.]

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Naslov (engleski)First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin
AutorDanijela Veljković Vujaklija
AutorTamara Gulić
AutorSonja Sucic
AutorKinya Nagata
AutorKazuyuki Ogawa
AutorGordana Laškarin
AutorShigeru Saito
AutorHerman Haller
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
Problem Granulysin (GNLY) is a novel cytolytic protein lytic against a variety of tumor cells and microbes. The role of GNLY during pregnancy has not been extensively explored. The aim of this study is to examine GNLY expression and distribution in the first trimester pregnancy peripheral blood (PB) and decidua, the ability of decidual and PB natural killer (NK) cells to secrete GNLY spontaneously, and the role of antigen-presenting cells (APC) in the regulation of GNLY expression in decidual NK cells. Method of study GNLY expression was analyzed using cell permeabilization method, flow cytometry, and immunohistochemistry. GNLY secretion by purified NK cells was detected by ELISA method. Results GNLY is abundantly expressed at the maternal–fetal interface in the first trimester pregnancy. Decidual T lymphocytes express significantly higher levels of GNLY (58%) then PB T lymphocytes (11%). Over 85% of decidual CD56+ cells express GNLY and when cultured spontaneously release high quantities of GNLY. Decidual APC participate in the control of GNLY expression in CD56+ cells. Conclusion Abundant expression of GNLY in the decidual immunocompetent cells and the capacity of decidual CD56+ cells to spontaneously secrete high quantities of GNLY point to important protective and immunomodulatory role that this molecule could play at the maternal–fetal interfac
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Reproductive Immunology
Brojčani podacivol. 66, br. 5, str. 363-372
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/j.1600-0897.2011.01015.x
URN:NBNurn:nbn:hr:184:738684
Datum objave publikacije2011-11
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2011.01015.x
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2023-09-18 10:28:39