prikaz prve stranice dokumenta TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
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TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
Nature Communications, 14 (2023), 1; 5016. https://doi.org/10.1038/s41467-023-40755-3
Worboys, Jonathan D.; Vowell, Katherine N.; Hare, Roseanna K.; Ambrose, Ashley R.; Bertuzzi, Margherita; Conner, Michael A.; Patel, Florence P.; Zammit, William H.; Gali-Moya, Judit; Hazime, Khodor S.; Jones, Katherine L.; Rey, Camille; Jonjić, Stipan; Roviš, Tihana Lenac; Tannahill, Gillian M.; Cruz De Matos, Gabriela Dos Santos; Waight, Jeremy D.; Davis, Daniel M. Više autora...

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Worboys, J. D., Vowell, K. N., Hare, R. K., Ambrose, A. R., Bertuzzi, M., Conner, M. A. ... Davis, D. M. (2023). TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nature Communications, 14. (1). doi: 10.1038/s41467-023-40755-3

Worboys, Jonathan D., et al. "TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation." Nature Communications, vol. 14, br. 1, 2023. https://doi.org/10.1038/s41467-023-40755-3

Worboys, Jonathan D., Katherine N. Vowell, Roseanna K. Hare, Ashley R. Ambrose, Margherita Bertuzzi, Michael A. Conner, Florence P. Patel, et al. "TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation." Nature Communications 14, br. 1 (2023). https://doi.org/10.1038/s41467-023-40755-3

Worboys, J. D., et al. (2023) 'TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation', Nature Communications, 14(1). doi: 10.1038/s41467-023-40755-3

Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, i sur.. TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nature Communications [Internet]. 18.08.2023. [pristupljeno 24.12.2024.];14(1). doi: 10.1038/s41467-023-40755-3

J. D. Worboys, et al., "TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation", Nature Communications, vol. 14, br. 1, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:636511. [Citirano: 24.12.2024.]

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Naslov (engleski)TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
AutorJonathan D. Worboys
AutorKatherine N. Vowell
AutorRoseanna K. Hare
AutorAshley R. Ambrose
AutorMargherita Bertuzzi
AutorMichael A. Conner
AutorFlorence P. Patel
AutorWilliam H. Zammit
AutorJudit Gali-Moya
AutorKhodor S. Hazime
AutorKatherine L. Jones
AutorCamille Rey
AutorStipan Jonjić
AutorTihana Lenac Roviš
AutorGillian M. Tannahill
AutorGabriela Dos Santos Cruz De Matos
AutorJeremy D. Waight
AutorDaniel M. Davis
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through competition of shared ligands. Whether TIGIT directly delivers cell intrinsic inhibitory signals in T cells remains unclear. Here we show, by ana lysing lymphocytes from matched human tumour and peripheral blood sam ples, that TIGIT and CD226 co-expression is rare on tumour-infiltrating lymphocytes. Using super-resolution microscopy and other techniques, we demonstrate that ligation with CD155 causes TIGIT to reorganise into dense nanoclusters, which coalesce with T cell receptor (TCR)-rich clusters at immune synapses. Functionally, this reduces cytokine secretion in a manner dependent on TIGIT’s intracellular ITT-like signalling motif. Thus, we provide evidence that TIGIT directly inhibits lymphocyte activation, acting indepen dently of CD226, requiring intracellular signalling that is proximal to the TCR. Within the subset of tumours where TIGIT-expressing cells do not commonly co-express CD226, this will likely be the dominant mechanism of action.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 14, br. 1, 5016
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-40755-3
URN:NBNurn:nbn:hr:184:636511
Datum objave publikacije2023-08-18
URL dokumentahttps://www.nature.com/articles/s41467-023-40755-3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-08-31 10:52:24