prikaz prve stranice dokumenta Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients
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Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients
Prostaglandins, Leukotrienes and Essential Fatty Acids, 194 (2023); 102578. https://doi.org/10.1016/j.plefa.2023.102578
Nadalin, Sergej; Zatković, Lena; Peitl, Vjekoslav; Karlović, Dalibor; Vidrih, Branka; Puljić, Antonia; Pavlić, Sanja Dević; Buretić-Tomljanović, Alena

Citirajte ovaj rad

Nadalin, S., Zatković, L., Peitl, V., Karlović, D., Vidrih, B., Puljić, A. ... Buretić Tomljanović, A. (2023). Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients. Prostaglandins, Leukotrienes and Essential Fatty Acids, 194.. doi: 10.1016/j.plefa.2023.102578

Nadalin, Sergej, et al. "Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients." Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 194, 2023. https://doi.org/10.1016/j.plefa.2023.102578

Nadalin, Sergej, Lena Zatković, Vjekoslav Peitl, Dalibor Karlović, Branka Vidrih, Antonia Puljić, Sanja Dević Pavlić i Alena Buretić Tomljanović. "Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients." Prostaglandins, Leukotrienes and Essential Fatty Acids 194 (2023). https://doi.org/10.1016/j.plefa.2023.102578

Nadalin, S., et al. (2023) 'Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients', Prostaglandins, Leukotrienes and Essential Fatty Acids, 194. doi: 10.1016/j.plefa.2023.102578

Nadalin S, Zatković L, Peitl V, Karlović D, Vidrih B, Puljić A, i sur.. Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients. Prostaglandins, Leukotrienes and Essential Fatty Acids [Internet]. 07.2023. [pristupljeno 05.05.2024.];194. doi: 10.1016/j.plefa.2023.102578

S. Nadalin, et al., "Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients", Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 194, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:599392. [Citirano: 05.05.2024.]

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Podaci o radu
Naslov (engleski)Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients
AutorSergej Nadalin
AutorLena Zatković
AutorVjekoslav Peitl
AutorDalibor Karlović
AutorBranka Vidrih
AutorAntonia Puljić
AutorSanja Dević Pavlić
AutorAlena Buretić-Tomljanović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Here we investigated whether antipsychotic treatment was influenced by three polymorphisms: rs10798059 (BanI) in the phospholipase A2 (PLA2)G4A gene, rs4375 in PLA2G6, and rs1549637 in PLA2G4C. A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis/restriction fragment length polymorphism. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). We found that PLA2G4A polymorphism influenced changes in PANSS psychopathology, and PLA2G6 polymorphism influenced changes in PANSS psychopathology and metabolic parameters. PLA2G4C polymorphism did not show any impact on PANSS psychopathology or metabolic parameters. The polymorphisms’ effect sizes were estimated as moderate to strong, with contributions ranging from around 6.2–15.7%. Furthermore, the polymorphisms’ effects manifested in a gender-specific manner.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProstaglandins, Leukotrienes and Essential Fatty Acids
Brojčani podacivol. 194, 102578
p-ISSN0952-3278
DOIhttps://doi.org/10.1016/j.plefa.2023.102578
URN:NBNurn:nbn:hr:184:599392
Datum objave publikacije2023-07
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0952327823000479
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-08-18 07:12:06