prikaz prve stranice dokumenta Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells
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Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells
Journal of Reproductive Immunology, 88 (2011), 1; 12-23. https://doi.org/10.1016/j.jri.2010.10.001
Laškarin, Gordana; Redžovic, Arnela; Vlastelić, Ivan; Haller, Herman; Medančić, Suzana Sršen; Solinas, Graziella; Rukavina, Daniel

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Laškarin, G., Redžovic, A., Vlastelić, I., Haller, H., Medančić, S. S., Solinas, G. i Rukavina, D. (2011). Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells. Journal of Reproductive Immunology, 88. (1), 12-23. doi: 10.1016/j.jri.2010.10.001

Laškarin, Gordana, et al. "Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells." Journal of Reproductive Immunology, vol. 88, br. 1, 2011, str. 12-23. https://doi.org/10.1016/j.jri.2010.10.001

Laškarin, Gordana, Arnela Redžovic, Ivan Vlastelić, Herman Haller, Suzana Sršen Medančić, Graziella Solinas i Daniel Rukavina. "Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells." Journal of Reproductive Immunology 88, br. 1 (2011): 12-23. https://doi.org/10.1016/j.jri.2010.10.001

Laškarin, G., et al. (2011) 'Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells', Journal of Reproductive Immunology, 88(1), str. 12-23. doi: 10.1016/j.jri.2010.10.001

Laškarin G, Redžovic A, Vlastelić I, Haller H, Medančić SS, Solinas G, i sur.. Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells. Journal of Reproductive Immunology [Internet]. 2011. [pristupljeno 05.05.2024.];88(1):12-23. doi: 10.1016/j.jri.2010.10.001

G. Laškarin, et al., "Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells", Journal of Reproductive Immunology, vol. 88, br. 1, str. 12-23, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:632689. [Citirano: 05.05.2024.]

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Naslov (engleski)Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells
AutorGordana Laškarin
AutorArnela Redžovic
AutorIvan Vlastelić
AutorHerman Haller
AutorSuzana Sršen Medančić
AutorGraziella Solinas
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Tumor-associated glycoprotein-72 (TAG-72) is physiologically present in secretory phase endometrium, but its presence and possible immunological role in early normal human pregnancy decidua has not received attention. The double labeling of paraffin-embedded early pregnancy decidua sections using B-72.4 anti-TAG-72 mAb and MNF 116 anticytokeratin mAb revealed the absence of TAG-72 in uterine decidua of normal and pathological pregnancies (non-embryonic pregnancy and missed abortion) at the implantation sites, although it was present in epithelial cells at and away from the tubal implantation site of an ectopic pregnancy. TAG-72 binds and internalizes by reacting with the mannose receptor (MR-CD206) or with DC-specific ICAM reacting non-integrin (DC-SIGN-CD209) on decidual CD1a+ cells. Decidual CD1a+ cells stimulated with TAG-72 decreased CD83 expression and diminished IL-15 and IFN- intracellular production. TAG-72-treated CD1a+ cells decreased IFN- production in syngenic decidual and allogenic cord blood T cells even in the presence of lipopolysaccharide. TAG-72- and lipopolysaccharide-pre-treated CD1a+ cells significantly increased IL-4 expression in allogenic cord blood T cells. TAG-72 increased allogenic cord blood T cell proliferation, mediated by decidual CD1a+ cells, compared with its effect on the proliferation of syngenic decidual T cells. All these data emphasize the anti-inflammatory properties of TAG-72-treated decidual CD1a+ cells in terms of their interaction with T cells. Thus, the absence of TAG-72 at the maternal–fetal interface during early pregnancy could lead to a mild pro-inflammatory response that may be beneficial for pregnancy success and trophoblast growth control.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Reproductive Immunology
Brojčani podacivol. 88, br. 1, str. 12-23
p-ISSN0165-0378
DOIhttps://doi.org/10.1016/j.jri.2010.10.001
URN:NBNurn:nbn:hr:184:632689
Datum objave publikacije2011
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0165037810003852
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2023-06-30 08:45:39