prikaz prve stranice dokumenta Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells
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Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells
American Journal of Reproductive Immunology, 74 (2015), 1; 38-53. https://doi.org/10.1111/aji.12374
Redžovic, Arnela; Gulić, Tamara; Laškarin, Gordana; Eminović, Senija; Haller, Herman; Rukavina, Daniel

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Redžovic, A., Gulić, T., Laškarin, G., Eminović, S., Haller, H. i Rukavina, D. (2015). Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells. American Journal of Reproductive Immunology, 74. (1), 38-53. doi: 10.1111/aji.12374

Redžovic, Arnela, et al. "Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells." American Journal of Reproductive Immunology, vol. 74, br. 1, 2015, str. 38-53. https://doi.org/10.1111/aji.12374

Redžovic, Arnela, Tamara Gulić, Gordana Laškarin, Senija Eminović, Herman Haller i Daniel Rukavina. "Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells." American Journal of Reproductive Immunology 74, br. 1 (2015): 38-53. https://doi.org/10.1111/aji.12374

Redžovic, A., et al. (2015) 'Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells', American Journal of Reproductive Immunology, 74(1), str. 38-53. doi: 10.1111/aji.12374

Redžovic A, Gulić T, Laškarin G, Eminović S, Haller H, Rukavina D. Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells. American Journal of Reproductive Immunology [Internet]. 07.2015. [pristupljeno 05.05.2024.];74(1):38-53. doi: 10.1111/aji.12374

A. Redžovic, T. Gulić, G. Laškarin, S. Eminović, H. Haller i D. Rukavina, "Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells", American Journal of Reproductive Immunology, vol. 74, br. 1, str. 38-53, Srpanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:440188. [Citirano: 05.05.2024.]

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Podaci o radu
Naslov (engleski)Heat-Shock Proteins 70 Induce Pro-Inflammatory Maturation Program in Decidual CD1a + Dendritic Cells
AutorArnela Redžovic
AutorTamara Gulić
AutorGordana Laškarin
AutorSenija Eminović
AutorHerman Haller
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
ProblemThe aim of the study was to assess possible binding of a mixture of constitutive Hsc70 and inducible Hsp70 forms (HSP70) to Toll-like receptor (TLR) 4 and CD91 receptors on decidual CD1a(+) dendritic cells (DCs) and their influence on DCs maturation status. Method of studyImmunohistology and immunofluorescence of paraffin-embedded first trimetester and term pregnancy decidua were performed together with flow cytometry detection of antigens in DCs after stimulation of decidual mononuclear cells with HSP70. ResultsHsc70 and Hsp70 labeling revealed intracellular and nuclear staining in trophoblast cells. The numbers of Hsc70(+) and Hsp70(+) cells of decidual tissue were higher in early pregnancy decidua than in decidua at term. HSP70 binds CD91 and TLR4 receptors on CD1a(+) DCs and increased the expression of CD83, HLA-DR, CD80, and CD86, but decreased CC receptor (CCR) 5. HSP70 increased CC ligand (CCL) 3 and CCL22. HSP70 in the concentration of 1g/mL increased the percentage of interferon- and interleukin (IL)-15-expressing cells over the cells expressing IL-4. ConclusionHSP70 binds CD91 and TLR4 on decidual CD1a(+) DCs, causes their maturation, and increases IL-15 in the context of Th1 cytokine/chemokine domination, which could support immune response harmful for ongoing pregnancy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Reproductive Immunology
Brojčani podacivol. 74, br. 1, str. 38-53
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/aji.12374
URN:NBNurn:nbn:hr:184:440188
Datum objave publikacije2015-07
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1111/aji.12374
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-06-26 12:32:18