prikaz prve stranice dokumenta Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma
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Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma
Clinical and Experimental Dermatology, 28 (2003), 3; 310-314. https://doi.org/10.1046/j.1365-2230.2003.01270.x
Jonjić, Nives; Zamolo, Gordana; Štifter, Sanja; Fučkar, Dora; Gruber, Franjo; Sasso, F.; Rizzardi, C.; Melato, M.

Citirajte ovaj rad

Jonjić, N., Zamolo, G., Štifter, S., Fučkar, D., Gruber, F., Sasso, F. ... Melato, M. (2003). Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma. Clinical and Experimental Dermatology, 28. (3), 310-314. doi: 10.1046/j.1365-2230.2003.01270.x

Jonjić, Nives, et al. "Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma." Clinical and Experimental Dermatology, vol. 28, br. 3, 2003, str. 310-314. https://doi.org/10.1046/j.1365-2230.2003.01270.x

Jonjić, Nives, Gordana Zamolo, Sanja Štifter, Dora Fučkar, Franjo Gruber, F. Sasso, C. Rizzardi i M. Melato. "Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma." Clinical and Experimental Dermatology 28, br. 3 (2003): 310-314. https://doi.org/10.1046/j.1365-2230.2003.01270.x

Jonjić, N., et al. (2003) 'Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma', Clinical and Experimental Dermatology, 28(3), str. 310-314. doi: 10.1046/j.1365-2230.2003.01270.x

Jonjić N, Zamolo G, Štifter S, Fučkar D, Gruber F, Sasso F, i sur.. Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma. Clinical and Experimental Dermatology [Internet]. 2003. [pristupljeno 13.11.2024.];28(3):310-314. doi: 10.1046/j.1365-2230.2003.01270.x

N. Jonjić, et al., "Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma", Clinical and Experimental Dermatology, vol. 28, br. 3, str. 310-314, 2003. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:278284. [Citirano: 13.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:278284
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Podaci o radu
Naslov (engleski)Cytomorphological variations, proliferation and angiogenesis in the prognosis of cutaneous melanoma
AutorNives Jonjić
AutorGordana Zamolo
AutorSanja Štifter
AutorDora Fučkar
AutorFranjo Gruber
AutorF. Sasso
AutorC. Rizzardi
AutorM. Melato
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Depth of invasion and stage of the disease are well known prognostic indicators in cutaneous melanoma (CM). However, the role of other parameters, such as the variations in cytomorphology of melanocyte tumours, mitotic activity and angiogenesis is still open to question. The aim of this study was to analyse proliferation by mitotic activity index (MAI) and immunostaining of proliferating cell nuclear antigen (PCNA), and the intensity of neovascularization (microvessel density ; MVD) in CM clinical stage I in relation to epithelioid, spindle and nevoid cell type, histological type (superficial spreading melanoma and nodular melanoma), Clark's level and Breslow thickness. Finally, the role of all parameters in the prognosis of CM was evaluated. Statistical analysis demonstrated that cytological characteristics of CM correlate only with Clark's level, while histological types correlate with MAI, PCNA and MVD. MAI and PCNA also showed correlation between groups according to Clark's level and Breslow thickness. Finally, tumour cell PCNA was found to correlate with MVD. Survival of patients with CM correlated significantly with MAI. These results suggest that cytological variation, histological type, PCNA and MVD alone are not independent prognostic parameters, whereas MAI is a potentially important prognostic marker in CM.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical and Experimental Dermatology
Brojčani podacivol. 28, br. 3, str. 310-314
p-ISSN0307-6938
e-ISSN1365-2230
DOIhttps://doi.org/10.1046/j.1365-2230.2003.01270.x
URN:NBNurn:nbn:hr:184:278284
Datum objave publikacije2003
URL dokumentahttp://bib.irb.hr/136050
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-05-18 12:29:13