prikaz prve stranice dokumenta Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer
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Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer
Scandinavian Journal of Immunology, 74 (2011), 4; 368-376. https://doi.org/10.1111/j.1365-3083.2011.02569.x
Sotošek Tokmadžić, Vlatka; Tomaš, M.I.; Sotošek, Stanislav; Laškarin, Gordana; Tulić, V.; Đorđević, Gordana; Šustić, Alan; Mrakovčić-Šutić, Ines

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Sotošek Tokmadžić, V., Tomaš, M., Sotošek, S., Laškarin, G., Tulić, V., Đorđević, G. ... Mrakovčić Šutić, I. (2011). Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer. Scandinavian Journal of Immunology, 74. (4), 368-376. doi: 10.1111/j.1365-3083.2011.02569.x

Sotošek Tokmadžić, Vlatka, et al. "Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer." Scandinavian Journal of Immunology, vol. 74, br. 4, 2011, str. 368-376. https://doi.org/10.1111/j.1365-3083.2011.02569.x

Sotošek Tokmadžić, Vlatka, M.I. Tomaš, Stanislav Sotošek, Gordana Laškarin, V. Tulić, Gordana Đorđević, Alan Šustić i Ines Mrakovčić Šutić. "Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer." Scandinavian Journal of Immunology 74, br. 4 (2011): 368-376. https://doi.org/10.1111/j.1365-3083.2011.02569.x

Sotošek Tokmadžić, V., et al. (2011) 'Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer', Scandinavian Journal of Immunology, 74(4), str. 368-376. doi: 10.1111/j.1365-3083.2011.02569.x

Sotošek Tokmadžić V, Tomaš M, Sotošek S, Laškarin G, Tulić V, Đorđević G, i sur.. Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer. Scandinavian Journal of Immunology [Internet]. 10.2011. [pristupljeno 21.10.2024.];74(4):368-376. doi: 10.1111/j.1365-3083.2011.02569.x

V. Sotošek Tokmadžić, et al., "Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer", Scandinavian Journal of Immunology, vol. 74, br. 4, str. 368-376, Listopad 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:227210. [Citirano: 21.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:227210
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Podaci o radu
Naslov (engleski)Different Perforin Expression in Peripheral Blood and Prostate Tissue in Patients with Benign Prostatic Hyperplasia and Prostate Cancer
AutorVlatka Sotošek Tokmadžić
AutorM.I. Tomaš
AutorStanislav Sotošek
AutorGordana Laškarin
AutorV. Tulić
AutorGordana Đorđević
AutorAlan Šustić
AutorInes Mrakovčić-Šutić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Perforin (P) is a prototypical cytotoxic molecule involved in cell-mediatedimmunity against various pathogens, alloantigens and particularly differenttumours. The purpose of this study was to determine P expression in differentlymphocyte subpopulations isolated from peripheral blood and prostate tissueof patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa)and compare it with the P expression found in the control group. Twenty sub-jects were recruited in each of the groups. Prostate mononuclear cells of theBPH and PCa tissues were isolated by enzymatic digestion and gradient den-sity centrifugation, whereas peripheral blood mononuclear cells were isolatedby gradient density centrifugation alone. Cells and tissue samples were labelledusing monoclonal antibodies against P and different surface antigens (CD3,CD4, CD8 and CD56) and analysed by immunofluorescence and flow cytome-try. Total P expression in peripheral blood lymphocytes did not differ signifi-cantly between BPH⁄PCa patients and control group, although the BPH andPCa tissue showed lower P expression level. A negative correlation betweenprostate-specific antigen levels and the overall percentage of P+, CD3+CD56)P+, and CD3)CD56+P+cells in the prostate tissue was observed onlyin patients with PCa. Our findings indicate that the low frequency of P+lym-phocytes, including T, NKT and NK cells, in the prostate tissue of patientswith BPH and, particularly, PCa could be the consequence of local tissuemicroenvironment and one of the mechanisms involved in the pathogenesis ofprostate hyperplasia following malignant alteration.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScandinavian Journal of Immunology
Brojčani podacivol. 74, br. 4, str. 368-376
p-ISSN0300-9475
DOIhttps://doi.org/10.1111/j.1365-3083.2011.02569.x
URN:NBNurn:nbn:hr:184:227210
Datum objave publikacije2011-10
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2011.02569.x
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2023-04-28 13:10:25