prikaz prve stranice dokumenta Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation
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Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation
Medical hypotheses, 175 (2023); 111078. https://doi.org/10.1016/j.mehy.2023.111078
Drvar, Vedrana; Legović, Dalen; Čanadi Jurešić, Gordana; Ćurko-Cofek, Božena; Kehler, Tatjana; Laškarin, Ana-Marija; Nemčić, Emilio; Laškarin, Gordana

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Drvar, V., Legović, D., Čanadi Jurešić, G., Ćurko Cofek, B., Kehler, T., Laškarin, A. M. ... Laškarin, G. (2023). Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation. Medical hypotheses, 175.. doi: 10.1016/j.mehy.2023.111078

Drvar, Vedrana, et al. "Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation." Medical hypotheses, vol. 175, 2023. https://doi.org/10.1016/j.mehy.2023.111078

Drvar, Vedrana, Dalen Legović, Gordana Čanadi Jurešić, Božena Ćurko Cofek, Tatjana Kehler, Ana Marija Laškarin, Emilio Nemčić i Gordana Laškarin. "Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation." Medical hypotheses 175 (2023). https://doi.org/10.1016/j.mehy.2023.111078

Drvar, V., et al. (2023) 'Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation', Medical hypotheses, 175. doi: 10.1016/j.mehy.2023.111078

Drvar V, Legović D, Čanadi Jurešić G, Ćurko Cofek B, Kehler T, Laškarin AM, i sur.. Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation. Medical hypotheses [Internet]. 15.04.2023. [pristupljeno 14.04.2024.];175. doi: 10.1016/j.mehy.2023.111078

V. Drvar, et al., "Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation", Medical hypotheses, vol. 175, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:493349. [Citirano: 14.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:493349
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Naslov (engleski)Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation
AutorVedrana Drvar
AutorDalen Legović
AutorGordana Čanadi Jurešić
AutorBožena Ćurko-Cofek
AutorTatjana Kehler
AutorAna-Marija Laškarin
AutorEmilio Nemčić
AutorGordana Laškarin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Osteoarthritis (OA) is a chronic joint disease caused by both mechanical damage and metabolic factors, which intertwine in their pathogenetic pathways. We hypothesise that the oxidised cholesterol derivative, 7-ketocholesterol (7-KCh), represents a danger signal in the synovia of patients with OA and promotes low-grade inflammation. The study would aim to elucidate the possible immune mechanisms initiated by 7-KCh that contribute to oxidative stress and inflammation in the synovia and synovial CD68+ cells, which are mostly macrophages. The polarisation of synovial CD68+ cells, their tissue distribution in relation to T and natural killer (NK) cells, and the influence of 7-KCh on the phenotype and intracellular cytokine and chemokine production in suspension is worth analysing. We envisage that this research would contribute to a better understanding of the biology of CD68+ macrophages influenced by 7-KCh and encourage the development of therapeutic approaches based on directing macrophage polarisation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical hypotheses
Brojčani podacivol. 175, 111078
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2023.111078
URN:NBNurn:nbn:hr:184:493349
Datum objave elektroničkog izdanja2023-04-15
URL dokumentahttp://bib.irb.hr/1267046
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-04-21 07:34:57