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prikaz prve stranice dokumenta Activation of Arf GTPases during murine cytomegalovirus infection
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Izlaganje na skupu
Activation of Arf GTPases during murine cytomegalovirus infection
Na: Annual meeting of the Croatian Immunological Society 2022. Sveti Martin na Muri, Hrvatska, 2022. urn:nbn:hr:184:023279
Blagojević Zagorac, Gordana; Gulić, Tamara; Pavišić, Valentino; Mahmutefendić Lučin, Hana; Lukanović Jurić, Silvija; Lučin, Pero

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Blagojević Zagorac, G., Gulić, T., Pavišić, V., Mahmutefendić Lučin, H., Lukanović Jurić, S. i Lučin, P. Activation of Arf GTPases during murine cytomegalovirus infection [PowerPoint prezentacija]. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:023279

Blagojević Zagorac, Gordana, et al. "Activation of Arf GTPases during murine cytomegalovirus infection." Annual meeting of the Croatian Immunological Society 2022, 23.09.2022.-25.09.2022., Sveti Martin na Muri, Hrvatska. Prezentacija. https://urn.nsk.hr/urn:nbn:hr:184:023279

Blagojević Zagorac, Gordana, Tamara Gulić, Valentino Pavišić, Hana Mahmutefendić Lučin, Silvija Lukanović Jurić i Pero Lučin. "Activation of Arf GTPases during murine cytomegalovirus infection." Prezentacija sa skupa Annual meeting of the Croatian Immunological Society 2022, Sveti Martin na Muri, Hrvatska, 23.09.2022.-25.09.2022. https://urn.nsk.hr/urn:nbn:hr:184:023279

Blagojević Zagorac, G., et al. 'Activation of Arf GTPases during murine cytomegalovirus infection' [Prezentacija], Annual meeting of the Croatian Immunological Society 2022. 23.09.2022.-25.09.2022. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:023279

Blagojević Zagorac G, Gulić T, Pavišić V, Mahmutefendić Lučin H, Lukanović Jurić S, Lučin P. Activation of Arf GTPases during murine cytomegalovirus infection. [Prezentacija] [pristupljeno 25.11.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:023279

G. Blagojević Zagorac, T. Gulić, V. Pavišić, H. Mahmutefendić Lučin, S. Lukanović Jurić i P. Lučin, "Activation of Arf GTPases during murine cytomegalovirus infection", prezentirano na: Annual meeting of the Croatian Immunological Society 2022, Sveti Martin na Muri, 23.09.2022.-25.09.2022. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:023279

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Naslov (engleski)Activation of Arf GTPases during murine cytomegalovirus infection
AutorGordana Blagojević Zagorac
AutorTamara Gulić
AutorValentino Pavišić
AutorHana Mahmutefendić Lučin
AutorSilvija Lukanović Jurić
AutorPero Lučin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Arf proteins are small GTP-binding proteins (GTPases) that are one of the main regulators of endocytosis and intracellular trafficking. They function as molecular switches, meaning that they continuously cycle between active (GTP) and inactive (GDP) form. When activated they bind to the membranes of endosomal compartments where they recruit their effector molecules. We have previously shown that Arf GTPases have important role in pathogenesis of murine cytomegalovirus (MCMV) infection. While Arf1 and Arf6 are important for the establishment of MCMV infection, Arf3 and Arf4 have important role in biogenesis of virion assembly compartment. The aim of this study was to determine the degree of Arf GTPases activation during MCMV infection. For that purpose, Balb 3T3 cells were infected with ∆m138 MCMV and at 0, 6, 16 and 30 hours post infection degree of Arf GTPases activation was determined by 3 different methods: subcellular fractionation, precipitation of Arf proteins with GGA3 PBD agarose beads and by analysing intracellular localization of Arf effector molecules. Our results have shown that the main effector molecules of Arf proteins are accumulated in the juxtanuclear area of MCMV infected cells with a pattern like that of the Arf proteins. Furthermore, the proportion of Arf proteins that are precipitated with GGA3 PBD agarose beads increases with progression of MCMV infection, suggesting that Arf proteins are overactivated during MCMV infection, although we did not observe an increase in membrane fraction of Arf proteins.
Jezikengleski
Vrsta recenzijeNepoznato
URN:NBNurn:nbn:hr:184:023279
Datum izlaganja2022-09-24
ProjektŠifra: IP-2020-02-1323
Naziv (hrvatski): Stanični sustav Arf GTPaza u patogenezi citomegalovirusne infekcije
Voditelj: Gordana Blagojević Zagorac
Pravna nadležnost: Hrvatska
Financijer: HRZZ
ProjektŠifra: IP-2019-04-3582
Naziv (hrvatski): Sekundarno omatanje i izlazak beta-herpesvirusa iz stanice
Voditelj: Pero Lučin
Pravna nadležnost: Hrvatska
Financijer: HRZZ
SkupNaziv: Annual meeting of the Croatian Immunological Society 2022
Lokacija: Sveti Martin na Muri, Hrvatska
Datum početka: 2022-09-23
Datum završetka: 2022-09-25
Vrsta izlaganja: Predavanje
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2023-04-05 13:06:00