prikaz prve stranice dokumenta Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection
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Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection
Na: The 15th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“. Zagreb, Hrvatska, 2021. urn:nbn:hr:184:495697
Pavišić, Valentino; Mahmutefendić Lučin, Hana; Jug Vučko, Natalia; Lučin, Pero; Blagojević Zagorac, Gordana

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Pavišić, V., Mahmutefendić Lučin, H., Jug Vučko, N., Lučin, P. i Blagojević Zagorac, G. Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection [PowerPoint prezentacija]. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:495697

Pavišić, Valentino, et al. "Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection." The 15th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“, 07.10.2021.-08.10.2021., Zagreb, Hrvatska. Prezentacija. https://urn.nsk.hr/urn:nbn:hr:184:495697

Pavišić, Valentino, Hana Mahmutefendić Lučin, Natalia Jug Vučko, Pero Lučin i Gordana Blagojević Zagorac. "Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection." Prezentacija sa skupa The 15th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“, Zagreb, Hrvatska, 07.10.2021.-08.10.2021. https://urn.nsk.hr/urn:nbn:hr:184:495697

Pavišić, V., et al. 'Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection' [Prezentacija], The 15th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“. 07.10.2021.-08.10.2021. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:495697

Pavišić V, Mahmutefendić Lučin H, Jug Vučko N, Lučin P, Blagojević Zagorac G. Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection. [Prezentacija] [pristupljeno 12.11.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:495697

V. Pavišić, H. Mahmutefendić Lučin, N. Jug Vučko, P. Lučin i G. Blagojević Zagorac, "Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection", prezentirano na: The 15th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“, Zagreb, 07.10.2021.-08.10.2021. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:495697

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Podaci o radu
Naslov (engleski)Arf proteins and their GEFs are generally excluded from outer part of murine cytomegalovirus assembly compartment in the late phase of MCMV infection
AutorValentino Pavišić
AutorHana Mahmutefendić Lučin
AutorNatalia Jug Vučko
AutorPero Lučin
AutorGordana Blagojević Zagorac
Autorova ustanovaSveučilište Sjever
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Introduction Arf proteins are small GTPases that function as molecular switches and cycle between their active (GTP) and inactive (GDP) form. Their activation is mediated by guanine nucleotide exchange factors (GEFs), and their inactivation is facilitated by the GTPase-activating proteins (GAPs). We have shown earlier that Arf proteins have important role in the development of murine cytomegalovirus (MCMV) assembly compartment (AC) in the early phase of infection. In the late phase of infection, late-phase viral proteins accumulate in the outer part of AC, which is one of the preconditions for the production of the new virions. Aims The aim of this study was to determine intracellular localization of Arf proteins and their GEFs in the late phase of MCMV infection and to determine if they accumulate in the same compartment as late-stage MCMV viral proteins. Materials and methods Balb 3T3 were infected with recombinant murine cytomegalovirus Δm138-MCMV and at 30 or 48 hours post infection (30 hpi or 48 hpi) intracellular localization of Arfs and Arf GEFs was analyzed by confocal microscopy. Arf proteins and their GEFs were colocalized with different late-phase viral proteins, including m55, m74 and m25. Results In the late phase of MCMV infection no significant colocalization of Arf proteins or Arf GEFs with late-phase MCMV viral proteins was observed. The only exception is Arf3 that showed partial colocalization with late-phase MCMV viral proteins. Conclusion Arf proteins, with exception of Arf3, and their GEFs are excluded from outer part of MCMV in the late phase of MCMV infection.
Jezikengleski
Vrsta recenzijeNepoznato
URN:NBNurn:nbn:hr:184:495697
Datum izlaganja2021-10-07
SkupNaziv: The 15th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“
Lokacija: Zagreb, Hrvatska
Datum početka: 2021-10-07
Datum završetka: 2021-10-08
Vrsta izlaganja: Predavanje
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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