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The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1
Viruses, 14 (2022), 8; 1661. https://doi.org/10.3390/v14081661
Zubković, Andreja; Žarak, Ines; Ratkaj, Ivana; Rokić, Filip; Jekić, Maja; Pribanić Matešić, Marina; Lebrón, Ricardo; Gómez-Martín, Cristina; Lisnić, Berislav; Lisnić Juranić, Vanda; Jonjić, Stipan; Pan, Dongli; Vugrek, Oliver; Hackenberg, Michael; Jurak, Igor Više autora...

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Zubković, A., Žarak, I., Ratkaj, I., Rokić, F., Jekić, M., Pribanić Matešić, M. ... Jurak, I. (2022). The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1. Viruses, 14. (8). doi: 10.3390/v14081661

Zubković, Andreja, et al. "The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1." Viruses, vol. 14, br. 8, 2022. https://doi.org/10.3390/v14081661

Zubković, Andreja, Ines Žarak, Ivana Ratkaj, Filip Rokić, Maja Jekić, Marina Pribanić Matešić, Ricardo Lebrón, et al. "The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1." Viruses 14, br. 8 (2022). https://doi.org/10.3390/v14081661

Zubković, A., et al. (2022) 'The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1', Viruses, 14(8). doi: 10.3390/v14081661

Zubković A, Žarak I, Ratkaj I, Rokić F, Jekić M, Pribanić Matešić M, i sur.. The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1. Viruses [Internet]. 28.07.2022. [pristupljeno 05.05.2024.];14(8). doi: 10.3390/v14081661

A. Zubković, et al., "The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1", Viruses, vol. 14, br. 8, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:571870. [Citirano: 05.05.2024.]

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Podaci o radu
Naslov (engleski)The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1
AutorAndreja Zubković
AutorInes Žarak
AutorIvana Ratkaj
AutorFilip Rokić
AutorMaja Jekić
AutorMarina Pribanić Matešić
AutorRicardo Lebrón
AutorCristina Gómez-Martín
AutorBerislav Lisnić
AutorVanda Lisnić Juranić
AutorStipan Jonjić
AutorDongli Pan
AutorOliver Vugrek
AutorMichael Hackenberg
AutorIgor Jurak
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Herpes simplex virus 1 (HSV-1) expresses a large number of miRNAs, and their function is still not completely understood. In addition, HSV-1 has been found to deregulate host miRNAs, which adds to the complexity of the regulation of efficient virus replication. In this study, we comprehensively addressed the deregulation of host miRNAs by massive-parallel sequencing. We found that only miRNAs expressed from a single cluster, miR-183/96/182, are reproducibly deregulated during productive infection. These miRNAs are predicted to regulate a great number of potential targets involved in different cellular processes and have only 33 shared targets. Among these, members of the FoxO family of proteins were identified as potential targets for all three miRNAs. However, our study shows that the upregulated miRNAs do not affect the expression of FoxO proteins, moreover, these proteins were upregulated in HSV-1 infection. Furthermore, we show that the individual FoxO proteins are not required for efficient HSV-1 replication. Taken together, our results indicate a complex and redundant response of infected cells to the virus infection that is efficiently inhibited by the virus.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 14, br. 8, 1661
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v14081661
URN:NBNurn:nbn:hr:184:571870
Datum objave publikacije2022-07-28
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
URL dokumentahttps://www.mdpi.com/1999-4915/14/8/1661
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-27 12:55:39