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Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
npj Vaccines, 8 (2023), 1; 8. https://doi.org/10.1038/s41541-023-00602-4
Le-Trilling, Vu Thuy Khanh; Jagnjić, Andreja; Brizić, Ilija; Eilbrecht, Mareike; Wohlgemuth, Kerstin; Rožmanić, Carmen; Herdman, Alan; Hoffmann, Katja; Westendorf, Astrid M.; Hengel, Hartmut; Jonjić, Stipan; Trilling, Mirko

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Le Trilling, V. T. K., Jagnjić, A., Brizić, I., Eilbrecht, M., Wohlgemuth, K., Rožmanić, C. ... Trilling, M. (2023). Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus. npj Vaccines, 8. (1). doi: 10.1038/s41541-023-00602-4

Le Trilling, Vu Thuy Khanh, et al. "Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus." npj Vaccines, vol. 8, br. 1, 2023. https://doi.org/10.1038/s41541-023-00602-4

Le Trilling, Vu Thuy Khanh, Andreja Jagnjić, Ilija Brizić, Mareike Eilbrecht, Kerstin Wohlgemuth, Carmen Rožmanić, Alan Herdman, et al. "Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus." npj Vaccines 8, br. 1 (2023). https://doi.org/10.1038/s41541-023-00602-4

Le Trilling, V. T. K., et al. (2023) 'Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus', npj Vaccines, 8(1). doi: 10.1038/s41541-023-00602-4

Le Trilling VTK, Jagnjić A, Brizić I, Eilbrecht M, Wohlgemuth K, Rožmanić C, i sur.. Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus. npj Vaccines [Internet]. 03.02.2023. [pristupljeno 06.05.2024.];8(1). doi: 10.1038/s41541-023-00602-4

V. T. K. Le Trilling, et al., "Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus", npj Vaccines, vol. 8, br. 1, Veljača 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:761822. [Citirano: 06.05.2024.]

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Naslov (engleski)Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
AutorVu Thuy Khanh Le-Trilling
AutorAndreja Jagnjić
AutorIlija Brizić
AutorMareike Eilbrecht
AutorKerstin Wohlgemuth
AutorCarmen Rožmanić
AutorAlan Herdman
AutorKatja Hoffmann
AutorAstrid M. Westendorf
AutorHartmut Hengel
AutorStipan Jonjić
AutorMirko Trilling
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human cytomegalovirus (HCMV) frequently causes congenital infections, resulting in birth defects and developmental disorders. A vaccine is needed, but unavailable. We analyzed the potential of CMV mutants, lacking their STAT2 antagonists to serve as live attenuated vaccine viruses in mice. Infections with attenuated viruses elicited strong ELISA-reactive binding IgG responses and induced neutralizing antibodies as well as antibodies stimulating cellular Fcγ receptors, including the antibody-dependent cellular cytotoxicity (ADCC)-eliciting receptors FcγRIII/CD16 and FcγRIV. Accordingly, vaccinated mice were fully protected against challenge infections. Female mice vaccinated prior to gestation transmitted CMV-specific IgG to their offspring, which protected the progeny from perinatal infections in a mouse model for congenital CMV disease. To define the role of maternal antibodies, female mice either capable or incapable of producing antibodies were vaccinated and subsequently bred to males of the opposite genotype. Challenge infections of the genotypically identical F1 generation revealed the indispensability of maternal antibodies for vaccine-induced protection against cytomegaloviruses.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisanpj Vaccines
Brojčani podacivol. 8, br. 1, 8
e-ISSN2059-0105
DOIhttps://doi.org/10.1038/s41541-023-00602-4
URN:NBNurn:nbn:hr:184:761822
Datum objave publikacije2023-02-03
URL dokumentahttps://www.nature.com/articles/s41541-023-00602-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-02-27 12:13:32