prikaz prve stranice dokumenta Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors
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Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors
Leukemia, 37 (2023); 606-617. https://doi.org/10.1038/s41375-023-01817-z
Martens, Anne W. J.; Kavazović, Inga; Krapić, Mia; Pack, Su Min; Arens, Ramon; Jongejan, Aldo; Moerland, Perry D.; Eldering, Eric; van der Windt, Gerritje J. W.; Wensveen, Felix M.; Peters, Fleur S.; Kater, Arnon P.

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Martens, A. W. J., Kavazović, I., Krapić, M., Pack, S. M., Arens, R., Jongejan, A. ... Kater, A. P. (2023). Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors. Leukemia, 37., 606-617. doi: 10.1038/s41375-023-01817-z

Martens, Anne W. J., et al. "Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors." Leukemia, vol. 37, 2023, str. 606-617. https://doi.org/10.1038/s41375-023-01817-z

Martens, Anne W. J., Inga Kavazović, Mia Krapić, Su Min Pack, Ramon Arens, Aldo Jongejan, Perry D. Moerland, et al. "Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors." Leukemia 37 (2023): 606-617. https://doi.org/10.1038/s41375-023-01817-z

Martens, A. W. J., et al. (2023) 'Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors', Leukemia, 37, str. 606-617. doi: 10.1038/s41375-023-01817-z

Martens AWJ, Kavazović I, Krapić M, Pack SM, Arens R, Jongejan A, i sur.. Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors. Leukemia [Internet]. 19.01.2023. [pristupljeno 15.11.2024.];37:606-617. doi: 10.1038/s41375-023-01817-z

A. W. J. Martens, et al., "Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors", Leukemia, vol. 37, str. 606-617, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:153022. [Citirano: 15.11.2024.]

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Naslov (engleski)Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors
AutorAnne W. J. Martens
AutorInga Kavazović
AutorMia Krapić
AutorSu Min Pack
AutorRamon Arens
AutorAldo Jongejan
AutorPerry D. Moerland
AutorEric Eldering
AutorGerritje J. W. van der Windt
AutorFelix M. Wensveen
AutorFleur S. Peters
AutorArnon P. Kater
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
T-cell dysregulation in chronic lymphocytic leukemia (CLL) associates with low response rates to autologous T cell-based therapies. How CLL affects antigen-specific T-cell responses remains largely unknown. We investigated (epi)genetic and functional consequences of antigen-specific T-cell responses in presence of CLL in vitro and in an adoptive-transfer murine model. Already at steady-state, antigen-experienced patient-derived T cells were skewed towards short-lived effector cells (SLEC) at the expense of memory-precursor effector cells (MPEC). Stimulation of these T cells in vitro showed rapid induction of effector genes and suppression of key memory transcription factors only in presence of CLL cells, indicating epigenetic regulation. This was investigated in vivo by following antigen-specific responses of naïve OT-I CD8+ cells to mCMV-OVA in presence/absence of TCL1 B-cell leukemia. Presence of leukemia resulted in increased SLEC formation, with disturbed inflammatory cytokine production. Chromatin and transcriptome profiling revealed strong epigenetic modifications, leading to activation of an effector and silencing of a memory profile through presence of CLL cells. Secondary challenge in vivo confirmed dysfunctional memory responses by antigen-experienced OT-I cells generated in presence of CLL. Altogether, we show that presence of CLL induces a short-lived effector phenotype and impaired memory responses by epigenetic reprogramming during primary responses.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLeukemia
Brojčani podacivol. 37, str. 606-617
p-ISSN0887-6924
e-ISSN1476-5551
DOIhttps://doi.org/10.1038/s41375-023-01817-z
URN:NBNurn:nbn:hr:184:153022
Datum objave publikacije2023-01-19
URL dokumentahttps://www.nature.com/articles/s41375-023-01817-z
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2023-02-27 11:05:07