prikaz prve stranice dokumenta Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
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Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
International journal of molecular sciences, 22 (2021); 12211. urn:nbn:hr:184:339322
Janković, Tamara; Dolenec, Petra; Rajič Bumber, Jelena; Gržeta, Nika; Križ, Jasna; Župan, Gordana; Pilipović, Kristina

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Janković, T., Dolenec, P., Rajič Bumber, J., Gržeta, N., Križ, J., Župan, G. i Pilipović, K. (2021). Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice. International journal of molecular sciences, 22.. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:339322

Janković, Tamara, et al. "Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice." International journal of molecular sciences, vol. 22, 2021. https://urn.nsk.hr/urn:nbn:hr:184:339322

Janković, Tamara, Petra Dolenec, Jelena Rajič Bumber, Nika Gržeta, Jasna Križ, Gordana Župan i Kristina Pilipović. "Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice." International journal of molecular sciences 22 (2021). https://urn.nsk.hr/urn:nbn:hr:184:339322

Janković, T., et al. (2021) 'Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice', International journal of molecular sciences, 22. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:339322 (Datum pristupa: 17.04.2024.)

Janković T, Dolenec P, Rajič Bumber J, Gržeta N, Križ J, Župan G, i sur.. Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice. International journal of molecular sciences [Internet]. 2021. [pristupljeno 17.04.2024.];22. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:339322

T. Janković, et al., "Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice", International journal of molecular sciences, vol. 22, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:339322. [Citirano: 17.04.2024.]

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Naslov (engleski)Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
Naslov (engleski)Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
AutorTamara Janković
AutorPetra Dolenec
AutorJelena Rajič Bumber
AutorNika Gržeta
AutorJasna Križ
AutorGordana Župan
AutorKristina Pilipović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Traumatic brain injury (TBI) is a disabling disorder and a major cause of death and disability in the world. Both single and repetitive traumas affect the brain acutely but can also lead to chronic neurodegenerative changes. Clinical studies have shown some dissimilarities in transactive response DNA binding protein 43 (TDP-43) expression patterns following single versus repetitive TBI. We explored the acute cortical post-traumatic changes of TDP-43 using the lateral fluid percussion injury (LFPI) model of single moderate TBI in adult male mice and investigated the association of TDP-43 with post-traumatic neuroinflammation and synaptic plasticity. In the ipsilateral cortices of animals following LFPI, we found changes in the cytoplasmic and nuclear levels of TDP-43 and the decreased expression of postsynaptic protein 95 within the first 3 d post-injury. Subacute pathological changes of TDP-43 in the hippocampi of animals following LFPI and in mice exposed to repetitive mild TBI (rmTBI) were studied. Changes in the hippocampal TDP-43 expression patterns at 14 d following different brain trauma procedures showed pathological alterations only after single moderate, but not following rmTBI. Hippocampal LFPI-induced TDP-43 pathology was not accompanied by the microglial reaction, contrary to the findings after rmTBI, suggesting that different types of brain trauma may cause diverse pathophysiological changes in the brain, specifically related to the TDP-43 protein as well as to the microglial reaction. Taken together, our findings may contribute to a better understanding of the pathophysiological events following brain trauma.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational journal of molecular sciences
Brojčani podacivol. 22, 12211
e-ISSN1422-0067
URN:NBNurn:nbn:hr:184:339322
Datum objave publikacije2021
URL dokumentahttp://bib.irb.hr/1156692
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-15 09:32:11