prikaz prve stranice dokumenta Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
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Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
International journal of molecular sciences, 24 (2023); 1903. https://doi.org/10.3390/ijms24031903
Jurič, Andreja; Brčić Karačonji, Irena; Gašić, Uroš; Milojković Opsenica, Dušanka; Prđun, Saša; Bubalo, Dragan; Lušić, Dražen; Vahčić, Nada; Kopjar, Nevenka

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Jurič, A., Brčić Karačonji, I., Gašić, U., Milojković Opsenica, D., Prđun, S., Bubalo, D. ... Kopjar, N. (2023). Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study. International journal of molecular sciences, 24.. doi: 10.3390/ijms24031903

Jurič, Andreja, et al. "Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study." International journal of molecular sciences, vol. 24, 2023. https://doi.org/10.3390/ijms24031903

Jurič, Andreja, Irena Brčić Karačonji, Uroš Gašić, Dušanka Milojković Opsenica, Saša Prđun, Dragan Bubalo, Dražen Lušić, Nada Vahčić i Nevenka Kopjar. "Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study." International journal of molecular sciences 24 (2023). https://doi.org/10.3390/ijms24031903

Jurič, A., et al. (2023) 'Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study', International journal of molecular sciences, 24. doi: 10.3390/ijms24031903

Jurič A, Brčić Karačonji I, Gašić U, Milojković Opsenica D, Prđun S, Bubalo D, i sur.. Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study. International journal of molecular sciences [Internet]. 18.01.2023. [pristupljeno 24.12.2024.];24. doi: 10.3390/ijms24031903

A. Jurič, et al., "Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study", International journal of molecular sciences, vol. 24, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:710801. [Citirano: 24.12.2024.]

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Naslov (engleski)Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
Naslov (engleski)Protective effects of Arbutus unedo L. honey in the alleviation of irinotecan-induced cytogenetic damage in human lymphocytes—An in vitro study
AutorAndreja Jurič
MBZ: 359286
AutorIrena Brčić Karačonji
MBZ: 236105
AutorUroš Gašić
AutorDušanka Milojković Opsenica
AutorSaša Prđun
MBZ: 334512
AutorDragan Bubalo
MBZ: 200480
AutorDražen Lušić
AutorNada Vahčić
MBZ: 125475
AutorNevenka Kopjar
MBZ: 195102
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zdravstvenu ekologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Strawberry tree (Arbutus unedo L.) honey (STH) has been used since ancient times as a folk medicine remedy, especially in certain Mediterranean countries. This honey, rich in phenolic content, is well recognized for its antioxidant, anti- inflammatory, and antimicrobial activities, and is used for the treatment of skin lesions as well as gastrointestinal and respiratory disorders. This study investigated whether STH alleviates genome damage in human peripheral blood lymphocytes produced by the cytotoxic drug irinotecan. The phenolic profile of STH was previously estimated by ultra-high-performance liquid chromatography coupled to a linear ion trap–Orbitrap hybrid mass spectrometer. The effects of STH were evaluated at three concentrations (1x, 5x, and 10x), based on the daily consumption of the honey by an adult person. After 2 h of in vitro exposure, standard lymphocyte cultures for the analysis of chromosome aberrations and the cytokinesis-block micronucleus cytome assay were established. Our results demonstrate that STH offered remarkable geno- and cytoprotection when administered with irinotecan. These findings are relevant for drawing preliminary conclusions regarding the in vitro safety of the tested honey. However, further studies are needed with the application of more complex experimental models.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational journal of molecular sciences
Brojčani podacivol. 24, 1903
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24031903
URN:NBNurn:nbn:hr:184:710801
Datum objave publikacije2023-01-18
URL dokumentahttp://bib.irb.hr/1246441
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2023-01-25 13:11:06