prikaz prve stranice dokumenta Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes
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Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes
Immunology Letters, 248 (2022); 45-55. https://doi.org/10.1016/j.imlet.2022.06.001
Gašparini, Dora; Kavazović, Inga; Barković, Igor; Maričić, Vitomir; Ivaniš, Viktor; Samsa, Dijana Travica; Peršić, Viktor; Polić, Bojan; Turk Wensveen, Tamara; Wensveen, Felix M.

Citirajte ovaj rad

Gašparini, D., Kavazović, I., Barković, I., Maričić, V., Ivaniš, V., Samsa, D. T. ... Wensveen, F. M. (2022). Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes. Immunology Letters, 248., 45-55. doi: 10.1016/j.imlet.2022.06.001

Gašparini, Dora, et al. "Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes." Immunology Letters, vol. 248, 2022, str. 45-55. https://doi.org/10.1016/j.imlet.2022.06.001

Gašparini, Dora, Inga Kavazović, Igor Barković, Vitomir Maričić, Viktor Ivaniš, Dijana Travica Samsa, Viktor Peršić, Bojan Polić, Tamara Turk Wensveen i Felix M. Wensveen. "Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes." Immunology Letters 248 (2022): 45-55. https://doi.org/10.1016/j.imlet.2022.06.001

Gašparini, D., et al. (2022) 'Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes', Immunology Letters, 248, str. 45-55. doi: 10.1016/j.imlet.2022.06.001

Gašparini D, Kavazović I, Barković I, Maričić V, Ivaniš V, Samsa DT, i sur.. Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes. Immunology Letters [Internet]. 08.2022. [pristupljeno 17.04.2024.];248:45-55. doi: 10.1016/j.imlet.2022.06.001

D. Gašparini, et al., "Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes", Immunology Letters, vol. 248, str. 45-55, Kolovoz 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:907774. [Citirano: 17.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:907774
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Podaci o radu
Naslov (engleski)Extreme anaerobic exercise causes reduced cytotoxicity and increased cytokine production by peripheral blood lymphocytes
AutorDora Gašparini https://orcid.org/0000-0002-0503-9516
AutorInga Kavazović
AutorIgor Barković
AutorVitomir Maričić
AutorViktor Ivaniš
AutorDijana Travica Samsa
AutorViktor Peršić
AutorBojan Polić
AutorTamara Turk Wensveen
AutorFelix M. Wensveen
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za rehabilitacijsku i sportsku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Exercise has many beneficial effects for our body, but can become detrimental at high intensity, especially for our immune system. Little is known about the underlying mechanism of impaired immune functionality under conditions of intense physical strain. Freedivers, people who dive to high depths on a single breath, perform extreme exercise under anaerobic conditions. In this study, we investigated the impact of freediving on the cytotoxic arm of the immune system. At rest, elite freedivers did not display changes in their immunological profile compared to non-diving controls. In contrast, after a freedive, granzyme B and IL-2 production were reduced, whereas IFNγ and TNF secretion were increased by cytotoxic immune cells. Using in vitro models mimicking freedive conditions, we could show that hypoxia in combination with stress hyperglycemia had a negative impact on Granzyme B secretion, whereas IL-2 production was inhibited by stress hormones. Our findings suggest that in response to extreme exercise, cytotoxic immune cells transiently change their functional profile to limit tissue damage.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunology Letters
Brojčani podacivol. 248, str. 45-55
p-ISSN0165-2478
DOIhttps://doi.org/10.1016/j.imlet.2022.06.001
URN:NBNurn:nbn:hr:184:907774
Datum objave publikacije2022-08
ProjektŠifra: IP-2016-06-8027
Naziv (hrvatski): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Naziv (engleski): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Kratica: T-MEMORY
Voditelj: Felix Martinus Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-CORONA-2020-04-2045
Naziv (hrvatski): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Naziv (engleski): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Kratica: CORONAWAI
Voditelj: Felix Martinus Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP-CORONA
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0165247822000827
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-10-26 07:04:59