prikaz prve stranice dokumenta Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients
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Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients
Periodicum biologorum, 117 (2015), 1; 73-79. urn:nbn:hr:184:727777
Cvijanović, Olga; Bićanić, Nenad; Crnčević Orlić, Željka; Klobučar- Majanović, Sanja; Turk Wensween, Tamara; Bubić, Ivan

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Cvijanović, O., Bićanić, N., Crnčević Orlić, Ž., Klobučar Majanović, S., Turk Wensween, T. i Bubić, I. (2015). Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients. Periodicum biologorum, 117. (1), 73-79. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:727777

Cvijanović, Olga, et al. "Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients." Periodicum biologorum, vol. 117, br. 1, 2015, str. 73-79. https://urn.nsk.hr/urn:nbn:hr:184:727777

Cvijanović, Olga, Nenad Bićanić, Željka Crnčević Orlić, Sanja Klobučar Majanović, Tamara Turk Wensween i Ivan Bubić. "Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients." Periodicum biologorum 117, br. 1 (2015): 73-79. https://urn.nsk.hr/urn:nbn:hr:184:727777

Cvijanović, O., et al. (2015) 'Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients', Periodicum biologorum, 117(1), str. 73-79. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:727777 (Datum pristupa: 06.12.2024.)

Cvijanović O, Bićanić N, Crnčević Orlić Ž, Klobučar Majanović S, Turk Wensween T, Bubić I. Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients. Periodicum biologorum [Internet]. 2015. [pristupljeno 06.12.2024.];117(1):73-79. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:727777

O. Cvijanović, N. Bićanić, Ž. Crnčević Orlić, S. Klobučar Majanović, T. Turk Wensween i I. Bubić, "Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients", Periodicum biologorum, vol. 117, br. 1, str. 73-79, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:727777. [Citirano: 06.12.2024.]

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Naslov (engleski)Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients
AutorOlga Cvijanović
AutorNenad Bićanić
AutorŽeljka Crnčević Orlić
AutorSanja Klobučar- Majanović
AutorTamara Turk Wensween
AutorIvan Bubić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background and Purpose: Statins are cholesterol-lowering drugs decreasing bone resorption by inhibition of the farnesyl diphosphate synthase step in the mevalonic acid pathway and therefore are believed to have beneficial effects on bone status. The objective was to examine the relationship between statin therapy duration and bone turnover markers in dyslipidemic patients. Patients and Methods: Two hundred and eighty subjects were divided into five groups depending on duration of statin therapy: (controls 0 yrs); (0.1-1.5 yrs); (2-5 yrs); (6-10 yrs); (11-30 yrs). ELISA method was applied on fasting serums using bone formation markers: Osteoprotegerin (pmol/l) and Osteocalcin (ng/ml) and bone resorption markers: sRANKL (pmol/l) and CrossLaps (ng/ml). In statistical analysis, multiple regressions were used. Results: A common influence of studied predictor variables was statistically significant for sRANKL, Serum CrossLaps and osteocalcin (P<0.001), while statistical significance was not found for osteoprotegerin. The largest shares of contributions were recorded in Model 2 for the statin group (40%) and BMI (36%) and in Model 1 for statin group (35%) and total cholesterol (28%). Conclusions: Statins showed favorable influence on osteocalcin and sRANKL, indicating improved bone metabolism in patients with longer duration of statin therapy.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPeriodicum biologorum
Brojčani podacivol. 117, br. 1, str. 73-79
p-ISSN0031-5362
e-ISSN1849-0964
URN:NBNurn:nbn:hr:184:727777
Datum objave publikacije2015
URL dokumentahttps://hrcak.srce.hr/139525
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-13 13:19:12