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IgG N-glycome changes during the course of severe COVID-19: An observational study
EBioMedicine, 81 (2022); 104101. https://doi.org/10.1016/j.ebiom.2022.104101
Petrović, Tea; Vijay, Amrita; Vučković, Frano; Trbojević-Akmačić, Irena; Ollivere, Benjamin J.; Marjanović, Damir; Bego, Tamer; Prnjavorac, Besim; Đerek, Lovorka; Markotić, Alemka; Lukšić, Ivica; Jurin, Ivana; Valdes, Ana M.; Hadžibegović, Irzal; Lauc, Gordan Više autora...

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Petrović, T., Vijay, A., Vučković, F., Trbojević Akmačić, I., Ollivere, B. J., Marjanović, D. ... Lauc, G. (2022). IgG N-glycome changes during the course of severe COVID-19: An observational study. EBioMedicine, 81.. doi: 10.1016/j.ebiom.2022.104101

Petrović, Tea, et al. "IgG N-glycome changes during the course of severe COVID-19: An observational study." EBioMedicine, vol. 81, 2022. https://doi.org/10.1016/j.ebiom.2022.104101

Petrović, Tea, Amrita Vijay, Frano Vučković, Irena Trbojević Akmačić, Benjamin J. Ollivere, Damir Marjanović, Tamer Bego, et al. "IgG N-glycome changes during the course of severe COVID-19: An observational study." EBioMedicine 81 (2022). https://doi.org/10.1016/j.ebiom.2022.104101

Petrović, T., et al. (2022) 'IgG N-glycome changes during the course of severe COVID-19: An observational study', EBioMedicine, 81. doi: 10.1016/j.ebiom.2022.104101

Petrović T, Vijay A, Vučković F, Trbojević Akmačić I, Ollivere BJ, Marjanović D, i sur.. IgG N-glycome changes during the course of severe COVID-19: An observational study. EBioMedicine [Internet]. 07.2022. [pristupljeno 06.04.2025.];81. doi: 10.1016/j.ebiom.2022.104101

T. Petrović, et al., "IgG N-glycome changes during the course of severe COVID-19: An observational study", EBioMedicine, vol. 81, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:980356. [Citirano: 06.04.2025.]

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Naslov (engleski)IgG N-glycome changes during the course of severe COVID-19: An observational study
AutorTea Petrović
AutorAmrita Vijay
AutorFrano Vučković
AutorIrena Trbojević-Akmačić
AutorBenjamin J. Ollivere
AutorDamir Marjanović
AutorTamer Bego
AutorBesim Prnjavorac
AutorLovorka Đerek
AutorAlemka Markotić
AutorIvica Lukšić
AutorIvana Jurin
AutorAna M. Valdes
AutorIrzal Hadžibegović
AutorGordan Lauc
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Javno zdravstvo
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a respiratory illness named coronavirus disease 2019 (COVID-19), which is one of the main global health problems since 2019. Glycans attached to the Fc portion of immunoglobulin G (IgG) are important modulators of IgG effector functions. Fc region binds to different receptors on the surface of various immune cells, dictating the type of immune response. Here, we performed a large longitudinal study to determine... Više whether the severity and duration of COVID-19 are associated with altered IgG glycosylation. Methods: Using ultra-high-performance liquid chromatography analysis of released glycans, we analysed the composition of the total IgG N-glycome longitudinally during COVID-19 from four independent cohorts. We analysed 77 severe COVID-19 cases from the HR1 cohort (74% males, median age 72, age IQR 25-80); 31 severe cases in the HR2 cohort (77% males, median age 64, age IQR 41-86), 18 mild COVID-19 cases from the UK cohort (17% males, median age 50, age IQR 26-71) and 28 mild cases from the BiH cohort (71% males, median age 60, age IQR 12-78). Findings: Multiple statistically significant changes in IgG glycome composition were observed during severe COVID-19. The most statistically significant changes included increased agalactosylation of IgG (meta-analysis 95% CI [0.03, 0.07], adjusted meta-analysis P= <0.0001), which regulates proinflammatory actions of IgG via complement system activation and indirectly as a lack of sialylation and decreased presence of bisecting N-acetylglucosamine on IgG (meta-analysis 95% CI [-0.11, -0.08], adjusted meta-analysis P= <0.0001), which indirectly affects antibody-dependent cell-mediated cytotoxicity. On the contrary, no statistically significant changes in IgG glycome composition were observed in patients with mild COVID-19. Interpretation: The IgG glycome in severe COVID-19 patients is statistically significantly altered in a way that it indicates decreased immunosuppressive action of circulating immunoglobulins. The magnitude of observed changes is associated with the severity of the disease, indicating that aberrant IgG glycome composition or changes in IgG glycosylation may be an important molecular mechanism in COVID-19. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEBioMedicine
Brojčani podacivol. 81, 104101
p-ISSN2352-3964
DOIhttps://doi.org/10.1016/j.ebiom.2022.104101
URN:NBNurn:nbn:hr:184:980356
Datum objave publikacije2022-07
ProjektŠifra: IP-CORONA-2020-04-2052
Naziv (hrvatski): Glikani kao biomarkeri i funkcionalni efektori teškog oblika COVID-19
Voditelj: Gordan Lauc
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP-CORONA
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2352396422002821
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-10-13 10:26:33
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