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SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study
Viruses, 14 (2022), 9; 1966. https://doi.org/10.3390/v14091966
Brlić, Paola Kučan; Pavletić, Martina; Lerga, Mate; Krstanović, Fran; Matešić, Marina Pribanić; Miklić, Karmela; Malić, Suzana; Mikša, Leonarda; Pajcur, Maja; Peruč, Dolores; Schubert, Maren; Bertoglio, Federico; Arapović, Jurica; Protić, Alen; Šustić, Alan; Milošević, Marko; Šain, Luka Čičin; Jonjić, Stipan; Lisnić, Vanda Juranić; Brizić, Ilija Više autora...

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Brlić, P. K., Pavletić, M., Lerga, M., Krstanović, F., Matešić, M. P., Miklić, K. ... Brizić, I. (2022). SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study. Viruses, 14. (9). doi: 10.3390/v14091966

Brlić, Paola Kučan, et al. "SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study." Viruses, vol. 14, br. 9, 2022. https://doi.org/10.3390/v14091966

Brlić, Paola Kučan, Martina Pavletić, Mate Lerga, Fran Krstanović, Marina Pribanić Matešić, Karmela Miklić, Suzana Malić, et al. "SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study." Viruses 14, br. 9 (2022). https://doi.org/10.3390/v14091966

Brlić, P. K., et al. (2022) 'SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study', Viruses, 14(9). doi: 10.3390/v14091966

Brlić PK, Pavletić M, Lerga M, Krstanović F, Matešić MP, Miklić K, i sur.. SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study. Viruses [Internet]. 04.09.2022. [pristupljeno 04.12.2024.];14(9). doi: 10.3390/v14091966

P. K. Brlić, et al., "SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study", Viruses, vol. 14, br. 9, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:927357. [Citirano: 04.12.2024.]

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Podaci o radu
Naslov (engleski)SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study
AutorPaola Kučan Brlić
AutorMartina Pavletić
AutorMate Lerga
AutorFran Krstanović
AutorMarina Pribanić Matešić
AutorKarmela Miklić
AutorSuzana Malić
AutorLeonarda Mikša
AutorMaja Pajcur
AutorDolores Peruč
AutorMaren Schubert
AutorFederico Bertoglio
AutorJurica Arapović
AutorAlen Protić
AutorAlan Šustić
AutorMarko Milošević
AutorLuka Čičin Šain
AutorStipan Jonjić
AutorVanda Juranić Lisnić
AutorIlija Brizić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
Studies assessing the dynamics and duration of antibody responses following SARS-CoV-2 infection or vaccination are an invaluable tool for vaccination schedule planning, assessment of risk groups and management of pandemics. In this study, we developed and employed ELISA assays to analyze the humoral responses to Nucleocapsid and Spike proteins in vaccinated health-care workers (HCW) and critically ill COVID-19 patients. Sera of more than 1000 HCWs and critically ill patients from the Clinical Hospital Center Rijeka were tested across a one-year period, encompassing the spread of major SARS-CoV-2 variants of concern (VOCs). We observed 97% of seroconversion in HCW cohort as well as sustained anti-Spike antibody response in vaccinees for more than 6 months. In contrast, the infection-induced anti-Nucleocapsid response was waning significantly in a six-month period. Furthermore, a substantial decrease in vaccinees’ anti-Spike antibodies binding to Spike protein of Omicron VOC was also observed. Critically ill COVID-19 patients had higher levels of anti-Spike and anti-Nucleocapsid antibodies compared to HCWs. No significant differences in anti-Spike and anti-Nucleocapsid antibody levels between the critically ill COVID-19 patients that were on non-invasive oxygen supplementation and those on invasive ventilation support were observed. However, stronger anti-Spike, but not anti-Nucleocapsid, antibody response correlated with a better disease outcome in the cohort of patients on invasive ventilation support. Altogether, our results contribute to the growing pool of data on humoral responses to SARS-CoV-2 infection and vaccination.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 14, br. 9, 1966
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v14091966
URN:NBNurn:nbn:hr:184:927357
Datum objave publikacije2022-09-04
ProjektŠifra: IP-CORONA-2020-04-2073
Naziv (hrvatski): Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2
Naziv (engleski): No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom
Kratica: CoV2mAbs
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP-CORONA
URL dokumentahttps://www.mdpi.com/1999-4915/14/9/1966
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-10 10:56:06