prikaz prve stranice dokumenta Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction
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Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction
Medical Hypotheses, 82 (2014), 1; 36-39. https://doi.org/10.1016/j.mehy.2013.10.030
Mikolašević, Ivana; Rački, Sanjin; Lukenda, V.; Pavletić-Persšč, M.; Milić, Sandra; Orlic, Lidija

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Mikolašević, I., Rački, S., Lukenda, V., Pavletić Persšč, M., Milić, S. i Orlic, L. (2014). Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction. Medical Hypotheses, 82. (1), 36-39. doi: 10.1016/j.mehy.2013.10.030

Mikolašević, Ivana, et al. "Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction." Medical Hypotheses, vol. 82, br. 1, 2014, str. 36-39. https://doi.org/10.1016/j.mehy.2013.10.030

Mikolašević, Ivana, Sanjin Rački, V. Lukenda, M. Pavletić Persšč, Sandra Milić i Lidija Orlic. "Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction." Medical Hypotheses 82, br. 1 (2014): 36-39. https://doi.org/10.1016/j.mehy.2013.10.030

Mikolašević, I., et al. (2014) 'Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction', Medical Hypotheses, 82(1), str. 36-39. doi: 10.1016/j.mehy.2013.10.030

Mikolašević I, Rački S, Lukenda V, Pavletić Persšč M, Milić S, Orlic L. Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction. Medical Hypotheses [Internet]. 01.2014. [pristupljeno 21.10.2024.];82(1):36-39. doi: 10.1016/j.mehy.2013.10.030

I. Mikolašević, S. Rački, V. Lukenda, M. Pavletić Persšč, S. Milić i L. Orlic, "Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction", Medical Hypotheses, vol. 82, br. 1, str. 36-39, Siječanj 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:615058. [Citirano: 21.10.2024.]

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Naslov (engleski)Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction
AutorIvana Mikolašević
AutorSanjin Rački
AutorV. Lukenda
AutorM. Pavletić-Persšč
AutorSandra Milić
AutorLidija Orlic
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development of new risk factors as well as worsening of preexisting risk factors after transplantation. A majority ot these patients develop metabolic syndrome within a year after the transplantation. The metabolic syndrome (MS) is associated with impaired renal allograft function and increased insulin resistance. Non alcoholic fatty liver disease (NAFLD) represents a liver manifestation of metabolic syndrome and it development is strongly associated with all components of MS in general population. The current importance of NAFLD and its link to the MS has encouraged an interest in its possible role in the development of atherosclerosis in recent years. Considering the fact that all components of MS are more common among renal transplant recipients compared to general population, it would be expected that RTR may have a much higher incidence of NAFLD compared to general population. We propose that the presence of NAFLD in RTR could be a strong predictor in cardiovascular morbidity and mortality. Also, according to the recent investigations about the possible link between NAFLD and chronic kidney disease, we hypothesis that NAFLD may be associated with deteriorating graft function, causing a chronic allograft nephropathy and graft loss. Common factors underlying the pathogenesis of NAFLD and chronic allograft dysfunction may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver. (C) 2013 Elsevier Ltd. All rights reserved.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaMedical Hypotheses
Brojčani podacivol. 82, br. 1, str. 36-39
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2013.10.030
URN:NBNurn:nbn:hr:184:615058
Datum objave publikacije2014-01
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0306987713005161
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-09-20 09:38:54