prikaz prve stranice dokumenta Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study
  Preuzmi
PDF 1.08 MB
Znanstveni rad - Izvorni znanstveni rad
Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study
World Journal of Clinical Cases, 10 (2022), 17; 5551-5565. https://doi.org/10.12998/wjcc.v10.i17.5551
Pavić, Tajana; Pelajić, Stipe; Blažević, Nina; Kralj, Dominik; Milošević, Milan; Mikolašević, Ivana; Lerotic, Ivan; Hrabar, Davor

Citiranost:
,
Citirajte ovaj rad

Pavić, T., Pelajić, S., Blažević, N., Kralj, D., Milošević, M., Mikolašević, I. ... Hrabar, D. (2022). Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study. World Journal of Clinical Cases, 10. (17), 5551-5565. doi: 10.12998/wjcc.v10.i17.5551

Pavić, Tajana, et al. "Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study." World Journal of Clinical Cases, vol. 10, br. 17, 2022, str. 5551-5565. https://doi.org/10.12998/wjcc.v10.i17.5551

Pavić, Tajana, Stipe Pelajić, Nina Blažević, Dominik Kralj, Milan Milošević, Ivana Mikolašević, Ivan Lerotic i Davor Hrabar. "Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study." World Journal of Clinical Cases 10, br. 17 (2022): 5551-5565. https://doi.org/10.12998/wjcc.v10.i17.5551

Pavić, T., et al. (2022) 'Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study', World Journal of Clinical Cases, 10(17), str. 5551-5565. doi: 10.12998/wjcc.v10.i17.5551

Pavić T, Pelajić S, Blažević N, Kralj D, Milošević M, Mikolašević I, i sur.. Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study. World Journal of Clinical Cases [Internet]. 2022. [pristupljeno 01.04.2025.];10(17):5551-5565. doi: 10.12998/wjcc.v10.i17.5551

T. Pavić, et al., "Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study", World Journal of Clinical Cases, vol. 10, br. 17, str. 5551-5565, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:230007. [Citirano: 01.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:230007
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study
AutorTajana Pavić
AutorStipe Pelajić
AutorNina Blažević
AutorDominik Kralj
AutorMilan Milošević
AutorIvana Mikolašević
AutorIvan Lerotic
AutorDavor Hrabar
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: Biliary obstruction is a relatively common condition that affects approximately 5 in 1000 people annually. Malnutrition is very common in patients with biliary obstruction and since it is associated with significant morbidity and mortality, it is important to identify factors and mechanisms involved in its development. Aim: To determine the influence of obstructive jaundice on the hormones controlling appetite and nutritive status. Methods: This was a prospective case control... Više study performed in a tertiary center in Zagreb, Croatia. Patients with biliary obstruction undergoing internal biliary drainage from September 2012 until August 2013 were enrolled. After excluding patients who developed procedure related complications or were lost in the follow-up, out of initial 73 patients, 55 patients were included in the analysis, including 34 with benign and 21 with malignant disease. Meanwhile, 40 non-jaundiced controls were also included. Appetite, nutritional status, and serum ghrelin, cholecystokinin (CCK), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) were determined at admission, 48 h and 28 d after internal biliary drainage. Chi square test was used for categorical variables. Continuous variables were analysed for normality by Kolmogorov-Smirnov test and relevant non-parametric (Mann-Whitney, Kruskal-Wallis, and Friedman) or parametric (t-test and analysis of variance) tests were used. Results: Patients with obstructive jaundice were significantly malnourished compared to controls, regardless of disease etiology. Plasma ghrelin and CCK levels were significantly higher in patients with obstructive jaundice. Serum bilirubin concentrations were negatively correlated with ghrelin levels and positively correlated with TNF-α, but had no correlation with CCK concentrations. After internal biliary drainage, a significant improvement of nutritional status was observed although serum concentrations of ghrelin, IL-6, and TNF-α remained significantly elevated even 28 d after the procedure. CCK levels in patients without malnutrition remained elevated 28 d after the procedure, but in patients with malnutrition, CCK levels decreased to levels comparable with those in the control group. We have not established any correlation between appetite and serum levels of ghrelin, CCK, IL-6, and TNF-α before and after biliary drainage. Conclusion: Possible abnormalities in ghrelin and CCK regulation may be associated with the development of malnutrition during the inflammatory response in patients with biliary obstruction. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Clinical Cases
Brojčani podacivol. 10, br. 17, str. 5551-5565
p-ISSN2307-8960
DOIhttps://doi.org/10.12998/wjcc.v10.i17.5551
URN:NBNurn:nbn:hr:184:230007
Datum objave publikacije2022
URL dokumentahttps://www.wjgnet.com/2307-8960/full/v10/i17/5551.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2022-09-16 09:09:54
accessibility

closePristupačnostrefresh

Ako želite spremiti trajne postavke, kliknite Spremi, ako ne - vaše će se postavke poništiti kad zatvorite preglednik.