Peyronie’s disease is a progressive fibrotic disorder of penile connective tissue characterized by the formation of collagen plaques on the tunica albuginea of the penis. The result is penile deformity and pain, which are often accompanied with erectile dysfunction. Although a numerous risk factors are associated with the development of Peyronie's disease, further research is still needed to better understand this disease. Peyronie's disease can limit sexual intercourse and impose a serious physical and mental burden on the patient. Therefore, it is necessary to gain the patient's trust and emphasize the benign nature of the disease to facilitate initial diagnosis and patient’s compliance in determining appropriate therapy. We can distinguish two phases of the disease: an early acute phase that can last one to 18 months and a later chronic phase. In acute phase, patients may experience penile pain as the plaque develops. During the chronic phase, the plaque becomes more organized, the curvature of the penis stabilizes and the pain usually subsides. Peyronie's disease often goes undiagnosed and even in accurately diagnosed patients, there is still no effective therapy. Non-surgical options are often used with variable results. Surgical treatment is reserved for those patients with stable disease, erectile dysfunction and penile deformity that impairs sexual function.